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- NCIT_C147562 IAO_0000115 "A proprietary, biodegradable, poly (lactic-co-glycolic acid) (PLGA) nanoparticle-based formulation composed of synthetic vaccine particles (SVP) encapsulating the macrolide antibiotic rapamycin (SVP-R), with immunosuppressant and drug-protective activities. Upon administration of SVP-R, the SVP moiety is selectively and preferentially taken up through endocytosis by antigen-presenting cells (APCs), located in the spleen and lymph nodes, specifically dendritic cells (DCs). Rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, prevents DC maturation, induces tolerogenic DCs, induces regulatory T-cells (Tregs), blocks activation of effector T-cells, induces B-cell tolerance, reduces B-cell activation, and prevents antibody formation, thereby inducing immune tolerance. When co-administered with a biological immunogenic drug known to induce the production of anti-drug antibodies (ADA), SVP-R is able to prevent ADA formation, which prevents the unwanted neutralizing effects of ADAs, increases efficacy of the biological drug, and permits sustained therapeutic activity and repeated administration of the biological drug. In the presence of a specific target antigen, SVP-R is able to prevent an antigen-specific immune response and induces antigen-specific immune tolerance. Compared to the administration of free rapamycin, SVP-R induces long-lasting immunological tolerance." @default.
- NCIT_C147562 NCIT_NHC0 "C147562" @default.
- NCIT_C147562 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C147562 NCIT_P107 "Synthetic Vaccine Particles-Rapamycin" @default.
- NCIT_C147562 NCIT_P108 "Synthetic Vaccine Particles-Rapamycin" @default.
- NCIT_C147562 NCIT_P208 "CL545396" @default.
- NCIT_C147562 NCIT_P329 "792481" @default.
- NCIT_C147562 NCIT_P330 "792481" @default.
- NCIT_C147562 NCIT_P399 "792481" @default.
- NCIT_C147562 normalizedInformationContent "100" @default.
- NCIT_C147562 referenceCount "1" @default.
- NCIT_C147562 hasExactSynonym "SEL 110" @default.
- NCIT_C147562 hasExactSynonym "SEL-110" @default.
- NCIT_C147562 hasExactSynonym "SEL110" @default.
- NCIT_C147562 hasExactSynonym "SVP-R" @default.
- NCIT_C147562 hasExactSynonym "SVP-Rapa" @default.
- NCIT_C147562 hasExactSynonym "SVP-Rapamycin" @default.
- NCIT_C147562 hasExactSynonym "Synthetic Vaccine Particles-Rapamycin" @default.
- NCIT_C147562 inSubset NCIT_C176424 @default.
- NCIT_C147562 type Class @default.
- NCIT_C147562 isDefinedBy ncit.owl @default.
- NCIT_C147562 label "Synthetic Vaccine Particles-Rapamycin" @default.
- NCIT_C147562 subClassOf NCIT_C1404 @default.
- NCIT_C147562 subClassOf NCIT_C147562 @default.
- NCIT_C147562 subClassOf NCIT_C163758 @default.
- NCIT_C147562 subClassOf NCIT_C1908 @default.
- NCIT_C147562 subClassOf NCIT_C1909 @default.
- NCIT_C147562 subClassOf NCIT_C2201 @default.
- NCIT_C147562 subClassOf NCIT_C274 @default.
- NCIT_C147562 subClassOf NCIT_C308 @default.
- NCIT_C147562 subClassOf NCIT_C471 @default.
- NCIT_C147562 subClassOf NCIT_C574 @default.
- NCIT_C147562 subClassOf NCIT_C61074 @default.