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- NCIT_C147563 IAO_0000115 "A humanized, bispecific monoclonal antibody (BsAb) against human CD3, a T-cell surface antigen, and the human cell surface glycoprotein CD38, a tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD38/anti-CD3 bispecific monoclonal antibody GBR 1342 binds to both CD3 on T-cells and CD38 expressed on certain tumor cells. This results in the cross-linking of T-cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis. GBR 1342 uses the proprietary bispecific engagement by antibodies based on the T-cell receptor (BEAT) platform." @default.
- NCIT_C147563 NCIT_A32 NCIT_C1909 @default.
- NCIT_C147563 NCIT_A7 NCIT_C84323 @default.
- NCIT_C147563 NCIT_NHC0 "C147563" @default.
- NCIT_C147563 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C147563 NCIT_P107 "Anti-CD38/CD3 Bispecific Monoclonal Antibody GBR 1342" @default.
- NCIT_C147563 NCIT_P108 "Anti-CD38/CD3 Bispecific Monoclonal Antibody GBR 1342" @default.
- NCIT_C147563 NCIT_P208 "CL545397" @default.
- NCIT_C147563 NCIT_P319 "7H3Q0M9END" @default.
- NCIT_C147563 NCIT_P322 "CTRP" @default.
- NCIT_C147563 NCIT_P322 "FDA" @default.
- NCIT_C147563 NCIT_P322 "GDC" @default.
- NCIT_C147563 NCIT_P329 "792483" @default.
- NCIT_C147563 NCIT_P330 "792483" @default.
- NCIT_C147563 NCIT_P375 "Anti-CD38/CD3 Bispecific Monoclonal Antibody GBR 1342" @default.
- NCIT_C147563 NCIT_P399 "792483" @default.
- NCIT_C147563 NCIT_R124 NCIT_C17710 @default.
- NCIT_C147563 NCIT_R124 NCIT_C17828 @default.
- NCIT_C147563 NCIT_R124 NCIT_C18219 @default.
- NCIT_C147563 NCIT_R124 NCIT_C19986 @default.
- NCIT_C147563 NCIT_R124 NCIT_C40474 @default.
- NCIT_C147563 normalizedInformationContent "100" @default.
- NCIT_C147563 referenceCount "1" @default.
- NCIT_C147563 hasExactSynonym "Anti-CD38 x Anti-CD3 Bispecific Monoclonal Antibody GBR 1342" @default.
- NCIT_C147563 hasExactSynonym "Anti-CD38/Anti-CD3 Bispecific Monoclonal Antibody GBR 1342" @default.
- NCIT_C147563 hasExactSynonym "Anti-CD38/CD3 Bispecific Monoclonal Antibody GBR 1342" @default.
- NCIT_C147563 hasExactSynonym "BEAT GBR 1342" @default.
- NCIT_C147563 hasExactSynonym "CD38xCD3 BsAb GBR 1342" @default.
- NCIT_C147563 hasExactSynonym "GBR 1342" @default.
- NCIT_C147563 hasExactSynonym "GBR-1342" @default.
- NCIT_C147563 hasExactSynonym "GBR1342" @default.
- NCIT_C147563 inSubset NCIT_C116977 @default.
- NCIT_C147563 inSubset NCIT_C116978 @default.
- NCIT_C147563 inSubset NCIT_C128784 @default.
- NCIT_C147563 inSubset NCIT_C157711 @default.
- NCIT_C147563 inSubset NCIT_C157712 @default.
- NCIT_C147563 inSubset NCIT_C176424 @default.
- NCIT_C147563 inSubset NCIT_C177537 @default.
- NCIT_C147563 inSubset NCIT_C63923 @default.
- NCIT_C147563 type Class @default.
- NCIT_C147563 isDefinedBy ncit.owl @default.
- NCIT_C147563 label "Anti-CD38/CD3 Bispecific Monoclonal Antibody GBR 1342" @default.
- NCIT_C147563 subClassOf NCIT_C112883 @default.
- NCIT_C147563 subClassOf NCIT_C129821 @default.
- NCIT_C147563 subClassOf NCIT_C129822 @default.
- NCIT_C147563 subClassOf NCIT_C1454 @default.
- NCIT_C147563 subClassOf NCIT_C147563 @default.
- NCIT_C147563 subClassOf NCIT_C155321 @default.
- NCIT_C147563 subClassOf NCIT_C163758 @default.
- NCIT_C147563 subClassOf NCIT_C164008 @default.
- NCIT_C147563 subClassOf NCIT_C1908 @default.
- NCIT_C147563 subClassOf NCIT_C1909 @default.
- NCIT_C147563 subClassOf NCIT_C201282 @default.
- NCIT_C147563 subClassOf NCIT_C20401 @default.
- NCIT_C147563 subClassOf NCIT_C274 @default.
- NCIT_C147563 subClassOf NCIT_C28227 @default.
- NCIT_C147563 subClassOf NCIT_C307 @default.
- NCIT_C147563 subClassOf NCIT_C308 @default.