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- NCIT_C147577 IAO_0000115 "A proprietary antibody-drug conjugate (ADC) composed of upinitatug , a proprietary, humanized monoclonal antibody against human sodium-dependent phosphate transport protein 2B (SLC34A2; NaPi2b), site-specifically linked, via a protease cleavable linker, to the proprietary cytotoxic aurastatin derivative auristatin F-HPA (AF-HPA; auristatin F-hydroxypropylamide), with potential antineoplastic activity. Upinitatug rilsodotin is produced via the proprietary dolaflexin ADC conjugation platform, which promotes the conjugation of between 10 and 15 AF-HPA payload molecules to each XMT-1535 antibody. Upon administration of upinitatug rilsodotin, the antibody moiety targets and binds to NaPi2b expressed on tumor cells. Upon binding, internalization by endosomes/lysosomes, and enzymatic cleavage, the AF-HPA binds to tubulin and inhibits microtubule polymerization, which results in G2/M phase arrest and apoptosis of NaPi2b-expressing tumor cells. NaPi2b, a tumor-associated antigen (TAA), is overexpressed on a variety of cancer cells and plays a key role in the transport of inorganic phosphate (Pi) and the maintenance of phosphate homeostasis." @default.
- NCIT_C147577 NCIT_A32 NCIT_C1909 @default.
- NCIT_C147577 NCIT_A7 NCIT_C101436 @default.
- NCIT_C147577 NCIT_NHC0 "C147577" @default.
- NCIT_C147577 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C147577 NCIT_P107 "Upinitatug Rilsodotin" @default.
- NCIT_C147577 NCIT_P108 "Upinitatug Rilsodotin" @default.
- NCIT_C147577 NCIT_P208 "CL545394" @default.
- NCIT_C147577 NCIT_P210 "2254119-00-9" @default.
- NCIT_C147577 NCIT_P319 "E8US1SQ3B5" @default.
- NCIT_C147577 NCIT_P322 "CTRP" @default.
- NCIT_C147577 NCIT_P322 "FDA" @default.
- NCIT_C147577 NCIT_P322 "GDC" @default.
- NCIT_C147577 NCIT_P329 "792493" @default.
- NCIT_C147577 NCIT_P330 "792493" @default.
- NCIT_C147577 NCIT_P375 "Antibody-drug Conjugate ADC XMT-1536" @default.
- NCIT_C147577 NCIT_P399 "792493" @default.
- NCIT_C147577 normalizedInformationContent "100" @default.
- NCIT_C147577 referenceCount "1" @default.
- NCIT_C147577 hasExactSynonym "ADC XMT-1536" @default.
- NCIT_C147577 hasExactSynonym "Anti-NaPi2b ADC XMT-1536" @default.
- NCIT_C147577 hasExactSynonym "Anti-NaPi2b/Auristatin F-HPA ADC XMT-1536" @default.
- NCIT_C147577 hasExactSynonym "UPINITATUG RILSODOTIN" @default.
- NCIT_C147577 hasExactSynonym "Upifitamab Rilsodotin" @default.
- NCIT_C147577 hasExactSynonym "Upinitatug Rilsodotin" @default.
- NCIT_C147577 hasExactSynonym "XMT 1536" @default.
- NCIT_C147577 hasExactSynonym "XMT-1536" @default.
- NCIT_C147577 hasExactSynonym "XMT1536" @default.
- NCIT_C147577 inSubset NCIT_C116977 @default.
- NCIT_C147577 inSubset NCIT_C116978 @default.
- NCIT_C147577 inSubset NCIT_C128784 @default.
- NCIT_C147577 inSubset NCIT_C157711 @default.
- NCIT_C147577 inSubset NCIT_C157712 @default.
- NCIT_C147577 inSubset NCIT_C176424 @default.
- NCIT_C147577 inSubset NCIT_C177537 @default.
- NCIT_C147577 inSubset NCIT_C63923 @default.
- NCIT_C147577 type Class @default.
- NCIT_C147577 isDefinedBy ncit.owl @default.
- NCIT_C147577 label "Upinitatug Rilsodotin" @default.
- NCIT_C147577 subClassOf NCIT_C129821 @default.
- NCIT_C147577 subClassOf NCIT_C129823 @default.
- NCIT_C147577 subClassOf NCIT_C147577 @default.
- NCIT_C147577 subClassOf NCIT_C1512 @default.
- NCIT_C147577 subClassOf NCIT_C1908 @default.
- NCIT_C147577 subClassOf NCIT_C1909 @default.
- NCIT_C147577 subClassOf NCIT_C274 @default.
- NCIT_C147577 subClassOf NCIT_C307 @default.
- NCIT_C147577 subClassOf NCIT_C308 @default.