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- NCIT_C148039 IAO_0000115 "An orally bioavailable antagonist of the adenosine A2A receptor (A2AR; ADORA2A), with potential immunomodulating and antineoplastic activities. Upon administration, imaradenant selectively binds to and inhibits A2AR expressed on T-lymphocytes. This blocks tumor-released adenosine from interacting with A2AR and prevents the adenosine/A2AR-mediated inhibition of T-lymphocytes. This results in the proliferation and activation of T-lymphocytes, and stimulates a T-cell-mediated immune response against tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits T-cell proliferation and activation. Adenosine is often overproduced by cancer cells and plays a key role in immunosuppression." @default.
- NCIT_C148039 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148039 NCIT_A7 NCIT_C38612 @default.
- NCIT_C148039 NCIT_NHC0 "C148039" @default.
- NCIT_C148039 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C148039 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148039 NCIT_P107 "Imaradenant" @default.
- NCIT_C148039 NCIT_P108 "Imaradenant" @default.
- NCIT_C148039 NCIT_P208 "CL545814" @default.
- NCIT_C148039 NCIT_P210 "1321514-06-0" @default.
- NCIT_C148039 NCIT_P319 "770140J08A" @default.
- NCIT_C148039 NCIT_P322 "CTRP" @default.
- NCIT_C148039 NCIT_P322 "FDA" @default.
- NCIT_C148039 NCIT_P322 "GDC" @default.
- NCIT_C148039 NCIT_P329 "794358" @default.
- NCIT_C148039 NCIT_P330 "794358" @default.
- NCIT_C148039 NCIT_P375 "Adenosine A2A Receptor Antagonist AZD4635" @default.
- NCIT_C148039 NCIT_P375 "Imaradenant" @default.
- NCIT_C148039 NCIT_P399 "794358" @default.
- NCIT_C148039 normalizedInformationContent "100" @default.
- NCIT_C148039 referenceCount "1" @default.
- NCIT_C148039 hasExactSynonym "A2AR Antagonist AZD4635" @default.
- NCIT_C148039 hasExactSynonym "AZD-4635" @default.
- NCIT_C148039 hasExactSynonym "AZD4635" @default.
- NCIT_C148039 hasExactSynonym "Adenosine A2A Receptor Antagonist AZD4635" @default.
- NCIT_C148039 hasExactSynonym "HTL-1071" @default.
- NCIT_C148039 hasExactSynonym "IMARADENANT" @default.
- NCIT_C148039 hasExactSynonym "Imaradenant" @default.
- NCIT_C148039 inSubset NCIT_C116977 @default.
- NCIT_C148039 inSubset NCIT_C116978 @default.
- NCIT_C148039 inSubset NCIT_C128784 @default.
- NCIT_C148039 inSubset NCIT_C157711 @default.
- NCIT_C148039 inSubset NCIT_C157712 @default.
- NCIT_C148039 inSubset NCIT_C176424 @default.
- NCIT_C148039 inSubset NCIT_C177537 @default.
- NCIT_C148039 inSubset NCIT_C63923 @default.
- NCIT_C148039 type Class @default.
- NCIT_C148039 isDefinedBy ncit.owl @default.
- NCIT_C148039 label "Imaradenant" @default.
- NCIT_C148039 subClassOf NCIT_C148039 @default.
- NCIT_C148039 subClassOf NCIT_C1908 @default.
- NCIT_C148039 subClassOf NCIT_C1909 @default.
- NCIT_C148039 subClassOf NCIT_C2139 @default.
- NCIT_C148039 subClassOf NCIT_C308 @default.