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- NCIT_C148138 IAO_0000115 "An orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, the BET inhibitor ODM-207 binds to the acetylated lysine recognition motifs in the bromodomains of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression of oncogenic drivers that are important for cell proliferation and survival. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of proliferation in BET-overexpressing tumor cells. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that bind to acetylated lysine residues in histones and play an important role during development and cellular growth. In tumor cells, BET proteins play a key role in the regulation of oncogene transcription and tumor cell proliferation." @default.
- NCIT_C148138 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148138 NCIT_NHC0 "C148138" @default.
- NCIT_C148138 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148138 NCIT_P108 "BET-bromodomain Inhibitor ODM-207" @default.
- NCIT_C148138 NCIT_P208 "CL550806" @default.
- NCIT_C148138 NCIT_P322 "GDC" @default.
- NCIT_C148138 NCIT_P329 "792467" @default.
- NCIT_C148138 NCIT_P330 "792467" @default.
- NCIT_C148138 NCIT_P375 "BET-bromodomain Inhibitor ODM-207" @default.
- NCIT_C148138 NCIT_P399 "792467" @default.
- NCIT_C148138 normalizedInformationContent "100" @default.
- NCIT_C148138 referenceCount "1" @default.
- NCIT_C148138 hasExactSynonym "BET Inhibitor ODM-207" @default.
- NCIT_C148138 hasExactSynonym "BET-bromodomain Inhibitor ODM-207" @default.
- NCIT_C148138 hasExactSynonym "Bromodomain and Extraterminal Domain Protein Inhibitor ODM-207" @default.
- NCIT_C148138 hasExactSynonym "ODM 207" @default.
- NCIT_C148138 hasExactSynonym "ODM-207" @default.
- NCIT_C148138 hasExactSynonym "ODM207" @default.
- NCIT_C148138 inSubset NCIT_C128784 @default.
- NCIT_C148138 inSubset NCIT_C157711 @default.
- NCIT_C148138 inSubset NCIT_C157712 @default.
- NCIT_C148138 inSubset NCIT_C176424 @default.
- NCIT_C148138 inSubset NCIT_C177537 @default.
- NCIT_C148138 type Class @default.
- NCIT_C148138 isDefinedBy ncit.owl @default.
- NCIT_C148138 label "BET-bromodomain Inhibitor ODM-207" @default.
- NCIT_C148138 subClassOf NCIT_C128462 @default.
- NCIT_C148138 subClassOf NCIT_C129824 @default.
- NCIT_C148138 subClassOf NCIT_C148138 @default.
- NCIT_C148138 subClassOf NCIT_C1908 @default.
- NCIT_C148138 subClassOf NCIT_C1909 @default.
- NCIT_C148138 subClassOf NCIT_C2189 @default.
- NCIT_C148138 subClassOf NCIT_C274 @default.