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- NCIT_C148141 IAO_0000115 "An immunoglobulin G1 (IgG1) bispecific human monoclonal antibody against human CD3, a T-cell surface antigen, and human C-type lectin domain family 12 member A (CLEC12A), a tumor-associated antigen (TAA) overexpressed on certain tumor cells, with potential antineoplastic activity. Upon administration, tepoditamab binds to both CD3 on T-cells and CLEC12A expressed on malignant cells, such as myeloid blasts, atypical progenitor cells and leukemic stem cells (LSCs). This results in the cross-linking of T-cells with tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against CLEC12A-expressing tumor cells. CLEC12A, a myeloid differentiation antigen and member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed on myeloid leukemia cells, but not on normal early hematopoietic progenitors, including hematopoietic stem cells (HSCs)." @default.
- NCIT_C148141 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148141 NCIT_A7 NCIT_C162378 @default.
- NCIT_C148141 NCIT_NHC0 "C148141" @default.
- NCIT_C148141 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C148141 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148141 NCIT_P107 "Tepoditamab" @default.
- NCIT_C148141 NCIT_P108 "Tepoditamab" @default.
- NCIT_C148141 NCIT_P208 "CL550807" @default.
- NCIT_C148141 NCIT_P210 "2044679-53-8" @default.
- NCIT_C148141 NCIT_P319 "LK0H7J2V3C" @default.
- NCIT_C148141 NCIT_P322 "CTRP" @default.
- NCIT_C148141 NCIT_P322 "FDA" @default.
- NCIT_C148141 NCIT_P322 "GDC" @default.
- NCIT_C148141 NCIT_P329 "792475" @default.
- NCIT_C148141 NCIT_P330 "792475" @default.
- NCIT_C148141 NCIT_P375 "Anti-CLEC12A/CD3 Bispecific Antibody MCLA117" @default.
- NCIT_C148141 NCIT_P375 "Tepoditamab" @default.
- NCIT_C148141 NCIT_P399 "792475" @default.
- NCIT_C148141 NCIT_R124 NCIT_C17710 @default.
- NCIT_C148141 NCIT_R124 NCIT_C17828 @default.
- NCIT_C148141 NCIT_R124 NCIT_C18219 @default.
- NCIT_C148141 NCIT_R124 NCIT_C19986 @default.
- NCIT_C148141 NCIT_R124 NCIT_C40474 @default.
- NCIT_C148141 normalizedInformationContent "100" @default.
- NCIT_C148141 referenceCount "1" @default.
- NCIT_C148141 hasExactSynonym "Anti-CLEC12A x CD3 Bispecific Antibody MCLA117" @default.
- NCIT_C148141 hasExactSynonym "Anti-CLEC12A/Anti-CD3 Bispecific Antibody MCLA117" @default.
- NCIT_C148141 hasExactSynonym "Bispecific Antibody MCLA-117" @default.
- NCIT_C148141 hasExactSynonym "Immunoglobulin G1, Bispecific, Anti-(C-type lectin CLEC12A and CD3 Antigen) (Human Monoclonal MCLA-117 Gamma1-chain), Disulfide with Human Monoclonal MCLA-117 Kappa-chain, Dimer" @default.
- NCIT_C148141 hasExactSynonym "MCLA 117" @default.
- NCIT_C148141 hasExactSynonym "MCLA-117" @default.
- NCIT_C148141 hasExactSynonym "MCLA117" @default.
- NCIT_C148141 hasExactSynonym "TEPODITAMAB" @default.
- NCIT_C148141 hasExactSynonym "Tepoditamab" @default.
- NCIT_C148141 inSubset NCIT_C116977 @default.
- NCIT_C148141 inSubset NCIT_C116978 @default.
- NCIT_C148141 inSubset NCIT_C128784 @default.
- NCIT_C148141 inSubset NCIT_C157711 @default.
- NCIT_C148141 inSubset NCIT_C157712 @default.
- NCIT_C148141 inSubset NCIT_C176424 @default.
- NCIT_C148141 inSubset NCIT_C177537 @default.
- NCIT_C148141 inSubset NCIT_C63923 @default.
- NCIT_C148141 type Class @default.
- NCIT_C148141 isDefinedBy ncit.owl @default.
- NCIT_C148141 label "Tepoditamab" @default.
- NCIT_C148141 subClassOf NCIT_C112883 @default.
- NCIT_C148141 subClassOf NCIT_C129821 @default.
- NCIT_C148141 subClassOf NCIT_C129822 @default.
- NCIT_C148141 subClassOf NCIT_C1454 @default.
- NCIT_C148141 subClassOf NCIT_C148141 @default.
- NCIT_C148141 subClassOf NCIT_C1908 @default.
- NCIT_C148141 subClassOf NCIT_C1909 @default.
- NCIT_C148141 subClassOf NCIT_C201282 @default.
- NCIT_C148141 subClassOf NCIT_C20401 @default.
- NCIT_C148141 subClassOf NCIT_C274 @default.
- NCIT_C148141 subClassOf NCIT_C28227 @default.
- NCIT_C148141 subClassOf NCIT_C307 @default.
- NCIT_C148141 subClassOf NCIT_C308 @default.