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- NCIT_C148145 IAO_0000115 "A radioconjugate composed of PSMA-617, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration of lutetium Lu 177 vipivotide tetraxetan, vipivotide tetraxetan targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells." @default.
- NCIT_C148145 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148145 NCIT_A7 NCIT_C17796 @default.
- NCIT_C148145 NCIT_NHC0 "C148145" @default.
- NCIT_C148145 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148145 NCIT_P107 "Lutetium Lu 177 Vipivotide Tetraxetan" @default.
- NCIT_C148145 NCIT_P108 "Lutetium Lu 177 Vipivotide Tetraxetan" @default.
- NCIT_C148145 NCIT_P208 "CL550803" @default.
- NCIT_C148145 NCIT_P210 "1703749-62-5" @default.
- NCIT_C148145 NCIT_P302 "adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor (AR) pathway inhibition and taxane-based chemotherapy." @default.
- NCIT_C148145 NCIT_P319 "G6UF363ECX" @default.
- NCIT_C148145 NCIT_P322 "CTRP" @default.
- NCIT_C148145 NCIT_P322 "FDA" @default.
- NCIT_C148145 NCIT_P322 "GDC" @default.
- NCIT_C148145 NCIT_P329 "792497" @default.
- NCIT_C148145 NCIT_P330 "792497" @default.
- NCIT_C148145 NCIT_P375 "Lutetium Lu 177-PSMA-617" @default.
- NCIT_C148145 NCIT_P399 "792497" @default.
- NCIT_C148145 normalizedInformationContent "100" @default.
- NCIT_C148145 referenceCount "1" @default.
- NCIT_C148145 hasExactSynonym "177Lu-PSMA-617" @default.
- NCIT_C148145 hasExactSynonym "177Lu-labeled PSMA-617" @default.
- NCIT_C148145 hasExactSynonym "AAA 617" @default.
- NCIT_C148145 hasExactSynonym "AAA-617" @default.
- NCIT_C148145 hasExactSynonym "AAA617" @default.
- NCIT_C148145 hasExactSynonym "LUTETIUM LU-177 VIPIVOTIDE TETRAXETAN" @default.
- NCIT_C148145 hasExactSynonym "Lu177-PSMA-617" @default.
- NCIT_C148145 hasExactSynonym "Lutetium Lu 177 Vipivotide Tetraxetan" @default.
- NCIT_C148145 hasExactSynonym "Lutetium Lu 177-PSMA-617" @default.
- NCIT_C148145 hasExactSynonym "Lutetium-177-PSMA-617" @default.
- NCIT_C148145 hasExactSynonym "Pluvicto" @default.
- NCIT_C148145 inSubset NCIT_C116977 @default.
- NCIT_C148145 inSubset NCIT_C116978 @default.
- NCIT_C148145 inSubset NCIT_C128784 @default.
- NCIT_C148145 inSubset NCIT_C157711 @default.
- NCIT_C148145 inSubset NCIT_C157712 @default.
- NCIT_C148145 inSubset NCIT_C176424 @default.
- NCIT_C148145 inSubset NCIT_C177537 @default.
- NCIT_C148145 inSubset NCIT_C63923 @default.
- NCIT_C148145 type Class @default.
- NCIT_C148145 isDefinedBy ncit.owl @default.
- NCIT_C148145 label "Lutetium Lu 177 Vipivotide Tetraxetan" @default.
- NCIT_C148145 subClassOf NCIT_C129819 @default.
- NCIT_C148145 subClassOf NCIT_C1446 @default.
- NCIT_C148145 subClassOf NCIT_C148145 @default.
- NCIT_C148145 subClassOf NCIT_C1908 @default.
- NCIT_C148145 subClassOf NCIT_C1909 @default.
- NCIT_C148145 subClassOf NCIT_C2124 @default.
- NCIT_C148145 subClassOf NCIT_C274 @default.