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- NCIT_C148146 IAO_0000115 "A vaccine composed of a peptide derived from the tumor-associated antigen (TAA) and immune checkpoint molecule programmed cell death-1 ligand 1 (PD-L1) combined with the immunoadjuvant montanide ISA-51, with potential immunomodulating and antineoplastic activities. Vaccination with PD-L1 peptide vaccine may activate the immune system to induce an immune response against PD-L1-expressing cells. This may increase and restore the proliferation and activation of various immune cells, including cytotoxic T-lymphocytes (CTLs), and may eradicate PD-L1-expressing tumor cells. PD-L1 is overexpressed on many human cancer cell types as well as on antigen presenting cells (APCs) and immunosuppressive cells in the tumor micro-environment (TME), such as regulatory T-cells (Tregs). PD-L1 binding to its cognate receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) on T-cells suppresses the immune system and results in increased immune evasion and decreased CTL activation. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens." @default.
- NCIT_C148146 NCIT_NHC0 "C148146" @default.
- NCIT_C148146 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C148146 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148146 NCIT_P108 "PD-L1 Peptide Vaccine" @default.
- NCIT_C148146 NCIT_P208 "CL550798" @default.
- NCIT_C148146 NCIT_P329 "792500" @default.
- NCIT_C148146 NCIT_P330 "792500" @default.
- NCIT_C148146 NCIT_P399 "792500" @default.
- NCIT_C148146 NCIT_R124 NCIT_C17828 @default.
- NCIT_C148146 NCIT_R124 NCIT_C17930 @default.
- NCIT_C148146 NCIT_R124 NCIT_C17937 @default.
- NCIT_C148146 NCIT_R124 NCIT_C18839 @default.
- NCIT_C148146 NCIT_R124 NCIT_C21124 @default.
- NCIT_C148146 NCIT_R124 NCIT_C45548 @default.
- NCIT_C148146 normalizedInformationContent "100" @default.
- NCIT_C148146 referenceCount "1" @default.
- NCIT_C148146 hasExactSynonym "PD-L1 Peptide Vaccine" @default.
- NCIT_C148146 hasExactSynonym "PD-L1 Peptide" @default.
- NCIT_C148146 inSubset NCIT_C128784 @default.
- NCIT_C148146 inSubset NCIT_C176424 @default.
- NCIT_C148146 type Class @default.
- NCIT_C148146 isDefinedBy ncit.owl @default.
- NCIT_C148146 label "PD-L1 Peptide Vaccine" @default.
- NCIT_C148146 subClassOf NCIT_C129820 @default.
- NCIT_C148146 subClassOf NCIT_C148146 @default.
- NCIT_C148146 subClassOf NCIT_C1663 @default.
- NCIT_C148146 subClassOf NCIT_C1752 @default.
- NCIT_C148146 subClassOf NCIT_C1908 @default.
- NCIT_C148146 subClassOf NCIT_C1909 @default.
- NCIT_C148146 subClassOf NCIT_C274 @default.
- NCIT_C148146 subClassOf NCIT_C307 @default.
- NCIT_C148146 subClassOf NCIT_C308 @default.
- NCIT_C148146 subClassOf NCIT_C923 @default.