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- NCIT_C148150 IAO_0000115 "A preparation of human autologous T-lymphocytes that are transduced with a gene encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the anti-NY-ESO-1 TCR-transduced autologous T-cells recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types, and is not, or is minimally, expressed in normal, healthy cells." @default.
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- NCIT_C148150 NCIT_P107 "Autologous NY-ESO-1 TCR-targeted T Lymphocytes" @default.
- NCIT_C148150 NCIT_P108 "Autologous NY-ESO-1 TCR-targeted T Lymphocytes" @default.
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- NCIT_C148150 hasExactSynonym "Autologous NY-ESO-1 TCR-targeted T Lymphocytes" @default.
- NCIT_C148150 hasExactSynonym "NY-ESO-1 T Cell Receptor Genetically Modified Autologous T Cells" @default.
- NCIT_C148150 inSubset NCIT_C116977 @default.
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- NCIT_C148150 type Class @default.
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- NCIT_C148150 label "Autologous NY-ESO-1 TCR-targeted T Lymphocytes" @default.
- NCIT_C148150 subClassOf NCIT_C129820 @default.
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