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- NCIT_C148154 IAO_0000115 "A peptide vaccine composed of IO103, a peptide vaccine derived from the tumor-associated antigen (TAA) programmed cell death-1 ligand 1 (PD-L1), IO102, the 21-mer peptide vaccine derived from the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO), and the immunoadjuvant montanide ISA-51, with potential immunomodulating and antineoplastic activities. Vaccination with the PD-L1/IDO peptide vaccine IO102-103 may activate the immune system to induce an immune response against PD-L1 and IDO-expressing cells. This may increase and restore the proliferation and activation of various immune cells, including cytotoxic T-lymphocytes (CTLs), and may eradicate PD-L1 and IDO-expressing tumor cells through a CTL-mediated immune response. PD-L1 is overexpressed on many human cancer cell types. PD-L1 binding to its cognate receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) on T-cells suppresses the immune system and results in increased immune evasion and decreased CTL activation. IDO, a cytosolic enzyme responsible for tryptophan catabolism and conversion of tryptophan into kynurenine, is overexpressed by a variety of tumor cell types and antigen presenting cells (APCs) and plays an important role in immunosuppression mainly through suppression of CTL activation; tryptophan depletion inhibits T-lymphocyte proliferation and activation, and suppresses the immune system. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens." @default.
- NCIT_C148154 NCIT_A7 NCIT_C79782 @default.
- NCIT_C148154 NCIT_A7 NCIT_C96024 @default.
- NCIT_C148154 NCIT_NHC0 "C148154" @default.
- NCIT_C148154 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C148154 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148154 NCIT_P107 "PD-L1/IDO Peptide Vaccine IO102-103" @default.
- NCIT_C148154 NCIT_P108 "PD-L1/IDO Peptide Vaccine IO102-103" @default.
- NCIT_C148154 NCIT_P208 "CL550790" @default.
- NCIT_C148154 NCIT_P322 "CTRP" @default.
- NCIT_C148154 NCIT_P329 "792518" @default.
- NCIT_C148154 NCIT_P330 "792518" @default.
- NCIT_C148154 NCIT_P399 "792518" @default.
- NCIT_C148154 NCIT_R124 NCIT_C17828 @default.
- NCIT_C148154 NCIT_R124 NCIT_C17930 @default.
- NCIT_C148154 NCIT_R124 NCIT_C17937 @default.
- NCIT_C148154 NCIT_R124 NCIT_C18839 @default.
- NCIT_C148154 NCIT_R124 NCIT_C21124 @default.
- NCIT_C148154 NCIT_R124 NCIT_C45548 @default.
- NCIT_C148154 normalizedInformationContent "100" @default.
- NCIT_C148154 referenceCount "1" @default.
- NCIT_C148154 hasExactSynonym "IDO/PD-L1 Peptide Vaccine IO 102 IO 103" @default.
- NCIT_C148154 hasExactSynonym "IO102 and IO103" @default.
- NCIT_C148154 hasExactSynonym "IO102-103" @default.
- NCIT_C148154 hasExactSynonym "IO102-IO103 Peptide Vaccine" @default.
- NCIT_C148154 hasExactSynonym "IO102-IO103" @default.
- NCIT_C148154 hasExactSynonym "IO102/IO103" @default.
- NCIT_C148154 hasExactSynonym "IO103/IO102 Peptide Vaccine" @default.
- NCIT_C148154 hasExactSynonym "PD-L1/IDO Peptide Vaccine IO102-103" @default.
- NCIT_C148154 hasExactSynonym "Peptide Vaccine IO102-IO103" @default.
- NCIT_C148154 hasExactSynonym "Peptide Vaccine IO103/IO102" @default.
- NCIT_C148154 inSubset NCIT_C116977 @default.
- NCIT_C148154 inSubset NCIT_C116978 @default.
- NCIT_C148154 inSubset NCIT_C128784 @default.
- NCIT_C148154 inSubset NCIT_C176424 @default.
- NCIT_C148154 type Class @default.
- NCIT_C148154 isDefinedBy ncit.owl @default.
- NCIT_C148154 label "PD-L1/IDO Peptide Vaccine IO102-103" @default.
- NCIT_C148154 subClassOf NCIT_C129820 @default.
- NCIT_C148154 subClassOf NCIT_C148154 @default.
- NCIT_C148154 subClassOf NCIT_C1663 @default.
- NCIT_C148154 subClassOf NCIT_C1752 @default.
- NCIT_C148154 subClassOf NCIT_C1908 @default.
- NCIT_C148154 subClassOf NCIT_C1909 @default.
- NCIT_C148154 subClassOf NCIT_C274 @default.
- NCIT_C148154 subClassOf NCIT_C307 @default.
- NCIT_C148154 subClassOf NCIT_C308 @default.
- NCIT_C148154 subClassOf NCIT_C923 @default.