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- NCIT_C148163 IAO_0000115 "A radioimmunoconjugate composed of ABT-806, a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the epidermal growth factor receptor (EGFR), labeled with the radioisotope zirconium Zr 89, with potential use as an imaging agent upon positron emission tomography (PET). Upon administration of zirconium Zr 89 anti-EGFR monoclonal antibody ABT-806, the antibody moiety binds to a specific EGFR epitope of either the wild-type or the variant III mutant (EGFRvIII; de2-7 EGFR; DEGFR) on tumor cells. Upon PET imaging, EGFR-expressing tumor cells can be visualized and assessed. This may result in the quantification of EGFR-expressing tumor cells, an assessment of the expected response to treatment with ABT-806 and the selection of patients that would respond to ABT-806. ABT-806 is the humanized version of chimeric monoclonal antibody 806. EGFR, a receptor tyrosine kinase overexpressed on the cell surfaces of many tumor cell types, plays a key role in tumor cell proliferation." @default.
- NCIT_C148163 NCIT_NHC0 "C148163" @default.
- NCIT_C148163 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C148163 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148163 NCIT_P108 "Zirconium Zr 89 Anti-EGFR Monoclonal Antibody ABT-806" @default.
- NCIT_C148163 NCIT_P208 "CL550781" @default.
- NCIT_C148163 NCIT_P329 "792536" @default.
- NCIT_C148163 NCIT_P330 "792536" @default.
- NCIT_C148163 NCIT_P399 "792536" @default.
- NCIT_C148163 normalizedInformationContent "100" @default.
- NCIT_C148163 referenceCount "1" @default.
- NCIT_C148163 hasExactSynonym "89Zr-ABT806" @default.
- NCIT_C148163 hasExactSynonym "89Zr-labeled ABT-806" @default.
- NCIT_C148163 hasExactSynonym "Zirconium Zr 89 Anti-EGFR Monoclonal Antibody ABT-806" @default.
- NCIT_C148163 inSubset NCIT_C176424 @default.
- NCIT_C148163 type Class @default.
- NCIT_C148163 isDefinedBy ncit.owl @default.
- NCIT_C148163 label "Zirconium Zr 89 Anti-EGFR Monoclonal Antibody ABT-806" @default.
- NCIT_C148163 subClassOf NCIT_C1446 @default.
- NCIT_C148163 subClassOf NCIT_C148163 @default.
- NCIT_C148163 subClassOf NCIT_C1511 @default.
- NCIT_C148163 subClassOf NCIT_C1512 @default.
- NCIT_C148163 subClassOf NCIT_C1908 @default.
- NCIT_C148163 subClassOf NCIT_C1909 @default.
- NCIT_C148163 subClassOf NCIT_C2124 @default.
- NCIT_C148163 subClassOf NCIT_C307 @default.
- NCIT_C148163 subClassOf NCIT_C308 @default.