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- NCIT_C148166 IAO_0000115 "An orally bioavailable inhibitor of cyclin dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, CDK8/19 inhibitor BCD 115 binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of certain tumor promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDKs are serine/threonine kinases involved in the regulation of the cell cycle and may be overexpressed in certain cancer cell types. CDK8 plays a key role in transcription regulation and is an important oncogenic driver in a variety of cancer cell types." @default.
- NCIT_C148166 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148166 NCIT_NHC0 "C148166" @default.
- NCIT_C148166 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148166 NCIT_P108 "Cyclin-dependent Kinase 8/19 Inhibitor BCD 115" @default.
- NCIT_C148166 NCIT_P208 "CL550778" @default.
- NCIT_C148166 NCIT_P210 "1449228-40-3" @default.
- NCIT_C148166 NCIT_P319 "E2X758P2BZ" @default.
- NCIT_C148166 NCIT_P322 "FDA" @default.
- NCIT_C148166 NCIT_P322 "GDC" @default.
- NCIT_C148166 NCIT_P329 "792544" @default.
- NCIT_C148166 NCIT_P330 "792544" @default.
- NCIT_C148166 NCIT_P375 "Cyclin-dependent Kinase 8/19 Inhibitor BCD 115" @default.
- NCIT_C148166 NCIT_P399 "792544" @default.
- NCIT_C148166 normalizedInformationContent "100" @default.
- NCIT_C148166 referenceCount "1" @default.
- NCIT_C148166 hasExactSynonym "BCD 115" @default.
- NCIT_C148166 hasExactSynonym "BCD-115" @default.
- NCIT_C148166 hasExactSynonym "BCD115" @default.
- NCIT_C148166 hasExactSynonym "CDK 8/19 Inhibitor BCD 115" @default.
- NCIT_C148166 hasExactSynonym "Cyclin-dependent Kinase 8/19 Inhibitor BCD 115" @default.
- NCIT_C148166 hasExactSynonym "SENEXIN B" @default.
- NCIT_C148166 inSubset NCIT_C128784 @default.
- NCIT_C148166 inSubset NCIT_C157711 @default.
- NCIT_C148166 inSubset NCIT_C157712 @default.
- NCIT_C148166 inSubset NCIT_C176424 @default.
- NCIT_C148166 inSubset NCIT_C177537 @default.
- NCIT_C148166 inSubset NCIT_C63923 @default.
- NCIT_C148166 type Class @default.
- NCIT_C148166 isDefinedBy ncit.owl @default.
- NCIT_C148166 label "Cyclin-dependent Kinase 8/19 Inhibitor BCD 115" @default.
- NCIT_C148166 subClassOf NCIT_C129824 @default.
- NCIT_C148166 subClassOf NCIT_C129825 @default.
- NCIT_C148166 subClassOf NCIT_C1404 @default.
- NCIT_C148166 subClassOf NCIT_C148166 @default.
- NCIT_C148166 subClassOf NCIT_C163758 @default.
- NCIT_C148166 subClassOf NCIT_C1908 @default.
- NCIT_C148166 subClassOf NCIT_C1909 @default.
- NCIT_C148166 subClassOf NCIT_C2185 @default.
- NCIT_C148166 subClassOf NCIT_C2189 @default.
- NCIT_C148166 subClassOf NCIT_C274 @default.
- NCIT_C148166 subClassOf NCIT_C471 @default.
- NCIT_C148166 subClassOf NCIT_C61074 @default.