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- NCIT_C148176 IAO_0000115 "A humanized, afucosylated monoclonal antibody created using the proprietary, sugar-engineered antibody (SEA) platform and directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), with potential immunoadjuvant activity. Upon administration, the anti-BCMA antibody SEA-BCMA targets and binds to BCMA expressed on tumor cells. When administered with antibody-coupled T-cell receptor (ACTR)-expressing T-cells, the ACTR-expressing T-cells bind, with high affinity, to the anti-BCMA antibody SEA-BCMA. This activates the ACTR T-cells and the T-cells induce specific cytotoxic T-lymphocyte (CTL)-mediated cytotoxicity toward BCMA-expressing tumor cells. BCMA, a cell surface protein and member of the tumor necrosis factor (TNF) receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival." @default.
- NCIT_C148176 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148176 NCIT_A7 NCIT_C97848 @default.
- NCIT_C148176 NCIT_NHC0 "C148176" @default.
- NCIT_C148176 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C148176 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148176 NCIT_P107 "Anti-BCMA Antibody SEA-BCMA" @default.
- NCIT_C148176 NCIT_P108 "Anti-BCMA Antibody SEA-BCMA" @default.
- NCIT_C148176 NCIT_P208 "CL550772" @default.
- NCIT_C148176 NCIT_P210 "2115084-53-0" @default.
- NCIT_C148176 NCIT_P319 "3C28VJ95EV" @default.
- NCIT_C148176 NCIT_P322 "CTRP" @default.
- NCIT_C148176 NCIT_P322 "FDA" @default.
- NCIT_C148176 NCIT_P322 "GDC" @default.
- NCIT_C148176 NCIT_P329 "793894" @default.
- NCIT_C148176 NCIT_P330 "793894" @default.
- NCIT_C148176 NCIT_P375 "Anti-BCMA Antibody SEA-BCMA" @default.
- NCIT_C148176 NCIT_P399 "793894" @default.
- NCIT_C148176 NCIT_R124 NCIT_C17710 @default.
- NCIT_C148176 NCIT_R124 NCIT_C17828 @default.
- NCIT_C148176 NCIT_R124 NCIT_C18219 @default.
- NCIT_C148176 NCIT_R124 NCIT_C19986 @default.
- NCIT_C148176 NCIT_R124 NCIT_C40474 @default.
- NCIT_C148176 normalizedInformationContent "100" @default.
- NCIT_C148176 referenceCount "1" @default.
- NCIT_C148176 hasExactSynonym "Anti-BCMA Afucosylated Monoclonal Antibody SEA-BCMA" @default.
- NCIT_C148176 hasExactSynonym "Anti-BCMA Antibody SEA-BCMA" @default.
- NCIT_C148176 hasExactSynonym "SEA-BCMA" @default.
- NCIT_C148176 inSubset NCIT_C116977 @default.
- NCIT_C148176 inSubset NCIT_C116978 @default.
- NCIT_C148176 inSubset NCIT_C128784 @default.
- NCIT_C148176 inSubset NCIT_C157711 @default.
- NCIT_C148176 inSubset NCIT_C157712 @default.
- NCIT_C148176 inSubset NCIT_C176424 @default.
- NCIT_C148176 inSubset NCIT_C177537 @default.
- NCIT_C148176 inSubset NCIT_C63923 @default.
- NCIT_C148176 type Class @default.
- NCIT_C148176 isDefinedBy ncit.owl @default.
- NCIT_C148176 label "Anti-BCMA Antibody SEA-BCMA" @default.
- NCIT_C148176 subClassOf NCIT_C129821 @default.
- NCIT_C148176 subClassOf NCIT_C129822 @default.
- NCIT_C148176 subClassOf NCIT_C148176 @default.
- NCIT_C148176 subClassOf NCIT_C163758 @default.
- NCIT_C148176 subClassOf NCIT_C181111 @default.
- NCIT_C148176 subClassOf NCIT_C181113 @default.
- NCIT_C148176 subClassOf NCIT_C1908 @default.
- NCIT_C148176 subClassOf NCIT_C1909 @default.
- NCIT_C148176 subClassOf NCIT_C20401 @default.
- NCIT_C148176 subClassOf NCIT_C274 @default.
- NCIT_C148176 subClassOf NCIT_C307 @default.
- NCIT_C148176 subClassOf NCIT_C308 @default.