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- NCIT_C148178 IAO_0000115 "A modified, replicative oncolytic vaccinia virus (VV), deleted of the genes for tyrosine kinase (TK) and ribonucleotide reductase (RR), and expressing the yeast-originated, bifunctional cytosine deaminase/uracil phosphoribosyltransferase gene (FCU1), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of the oncolytic vaccinia virus TG6002, the virus preferentially targets and infects tumor cells, causing oncolysis. In turn, the lysed tumor cells release various tumor-associated antigens (TAAs), which induce an immune response against the tumor cells. Upon concomitant administration of the non-cytotoxic prodrug flucytosine (5-fluorocytosine; 5-FC), the FCU1 expressed in the infected cancer cells produce the enzymes cytosine deaminase and uracil phosphoribosyltransferase which catalyze the conversion of 5-FC into the cytotoxic forms 5-fluorouracil (5-FU) and 5-fluoro-uridilyl monophosphate (5-FUMP); 5-FU and 5-FUMP exert a cytotoxic effect in the infected tumor cells. Double gene deletion (TK-RR-) restricts the propagation of TG6002 to the tumor cells, thereby reducing toxicity to normal cells." @default.
- NCIT_C148178 NCIT_NHC0 "C148178" @default.
- NCIT_C148178 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148178 NCIT_P106 "Virus" @default.
- NCIT_C148178 NCIT_P108 "Oncolytic Vaccinia Virus TG6002" @default.
- NCIT_C148178 NCIT_P208 "CL550766" @default.
- NCIT_C148178 NCIT_P329 "792489" @default.
- NCIT_C148178 NCIT_P330 "792489" @default.
- NCIT_C148178 NCIT_P399 "792489" @default.
- NCIT_C148178 normalizedInformationContent "100" @default.
- NCIT_C148178 referenceCount "1" @default.
- NCIT_C148178 hasExactSynonym "Oncolytic FCU1-expressing TK-RR-deleted Vaccinia Virus TG6002" @default.
- NCIT_C148178 hasExactSynonym "Oncolytic Vaccinia Virus TG6002" @default.
- NCIT_C148178 hasExactSynonym "T 601" @default.
- NCIT_C148178 hasExactSynonym "T-601" @default.
- NCIT_C148178 hasExactSynonym "T601" @default.
- NCIT_C148178 hasExactSynonym "TG 6002" @default.
- NCIT_C148178 hasExactSynonym "TG-6002" @default.
- NCIT_C148178 hasExactSynonym "TG6002" @default.
- NCIT_C148178 hasExactSynonym "Vaccinia Virus TG6002" @default.
- NCIT_C148178 inSubset NCIT_C176424 @default.
- NCIT_C148178 type Class @default.
- NCIT_C148178 isDefinedBy ncit.owl @default.
- NCIT_C148178 label "Oncolytic Vaccinia Virus TG6002" @default.
- NCIT_C148178 subClassOf NCIT_C129821 @default.
- NCIT_C148178 subClassOf NCIT_C148178 @default.
- NCIT_C148178 subClassOf NCIT_C1908 @default.
- NCIT_C148178 subClassOf NCIT_C1909 @default.
- NCIT_C148178 subClassOf NCIT_C1962 @default.
- NCIT_C148178 subClassOf NCIT_C274 @default.
- NCIT_C148178 subClassOf NCIT_C307 @default.
- NCIT_C148178 subClassOf NCIT_C717 @default.