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- NCIT_C148215 IAO_0000115 "A preparation of allogeneic, umbilical cord blood (CB)-derived natural killer cells (NKs) transduced with a retroviral vector expressing interleukin-15 (IL-15) and encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 that is coupled to the co-stimulatory domains of CD28 and to the zeta chain of the TCR/CD3 complex (CD3-zeta), and is linked to the suicide gene inducible caspase 9 (iCasp9; iC9), with potential immunomodulating and antineoplastic activities. Upon transfusion, the allogeneic iC9/CD19-CAR-CD28-zeta-2A-IL15-transduced CB-NKs TAK-007 recognize, bind to and induce selective cytotoxicity in CD19-expressing tumor cells. The iCasp9 safety switch consists of a full-length caspase 9, including its caspase recruitment domain, linked to a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V). If the administered NK cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered; AP1903 binds to the FKBP12-F36V drug-binding domain, activates caspase 9, and results in apoptosis of the administered NK cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. IL-15 enhances the cytotoxic effect of the NK cells." @default.
- NCIT_C148215 NCIT_A7 NCIT_C38894 @default.
- NCIT_C148215 NCIT_NHC0 "C148215" @default.
- NCIT_C148215 NCIT_P106 "Cell" @default.
- NCIT_C148215 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148215 NCIT_P107 "Allogeneic iC9/CD19-CAR-CD28-zeta-2A-IL15-transduced Cord Blood-derived Natural Killer Cells TAK-007" @default.
- NCIT_C148215 NCIT_P108 "Allogeneic iC9/CD19-CAR-CD28-zeta-2A-IL15-transduced Cord Blood-derived Natural Killer Cells TAK-007" @default.
- NCIT_C148215 NCIT_P208 "CL550854" @default.
- NCIT_C148215 NCIT_P322 "CTRP" @default.
- NCIT_C148215 NCIT_P329 "792530" @default.
- NCIT_C148215 NCIT_P330 "792530" @default.
- NCIT_C148215 NCIT_P399 "792530" @default.
- NCIT_C148215 normalizedInformationContent "100" @default.
- NCIT_C148215 referenceCount "1" @default.
- NCIT_C148215 hasExactSynonym "Allogeneic iC9/CAR19/IL15-transduced CB-NK Cells" @default.
- NCIT_C148215 hasExactSynonym "Allogeneic iC9/CD19-CAR-CD28-zeta-2A-IL15-transduced Cord Blood-derived Natural Killer Cells TAK-007" @default.
- NCIT_C148215 hasExactSynonym "CAR-CD19-CD28-zeta-2A-iCasp9-IL15-transduced CB-NK Cells" @default.
- NCIT_C148215 hasExactSynonym "TAK 007" @default.
- NCIT_C148215 hasExactSynonym "TAK-007" @default.
- NCIT_C148215 hasExactSynonym "TAK007" @default.
- NCIT_C148215 hasExactSynonym "UCB-derived CAR-CD19-CD28-zeta-2A-iCasp9-IL15 Engineered NK Cells" @default.
- NCIT_C148215 hasExactSynonym "iC9/CAR-CD19-CD28-zeta-2A/IL-15 CB-NK Cells" @default.
- NCIT_C148215 hasExactSynonym "iC9/CAR.19/IL15-transduced CB-NK Cells" @default.
- NCIT_C148215 hasExactSynonym "iC9/CAR19/IL15-transduced CB-NKs" @default.
- NCIT_C148215 inSubset NCIT_C116977 @default.
- NCIT_C148215 inSubset NCIT_C116978 @default.
- NCIT_C148215 inSubset NCIT_C128784 @default.
- NCIT_C148215 inSubset NCIT_C176424 @default.
- NCIT_C148215 type Class @default.
- NCIT_C148215 isDefinedBy ncit.owl @default.
- NCIT_C148215 label "Allogeneic iC9/CD19-CAR-CD28-zeta-2A-IL15-transduced Cord Blood-derived Natural Killer Cells TAK-007" @default.
- NCIT_C148215 subClassOf NCIT_C129820 @default.
- NCIT_C148215 subClassOf NCIT_C129821 @default.
- NCIT_C148215 subClassOf NCIT_C129826 @default.
- NCIT_C148215 subClassOf NCIT_C142078 @default.
- NCIT_C148215 subClassOf NCIT_C148215 @default.
- NCIT_C148215 subClassOf NCIT_C1908 @default.
- NCIT_C148215 subClassOf NCIT_C1909 @default.
- NCIT_C148215 subClassOf NCIT_C201545 @default.
- NCIT_C148215 subClassOf NCIT_C274 @default.
- NCIT_C148215 subClassOf NCIT_C28676 @default.
- NCIT_C148215 subClassOf NCIT_C307 @default.
- NCIT_C148215 subClassOf NCIT_C308 @default.