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- NCIT_C148239 IAO_0000115 "An mRNA-based therapeutic personalized cancer vaccine (PCV) targeting up to fifteen tumor-associated antigens (TAAs) that are specifically expressed by a patient's cancer cells, with potential immunostimulatory and antineoplastic activities. The cells from the patient's tumor are analyzed and subjected to RNA sequencing to identify mutant and immunogenic epitopes. The neoantigen epitopes are screened to select those that induce a strong immune response in tumor- infiltrating lymphocytes (TILs) isolated from the patient. The selected mRNA sequences encoding up to fifteen neoantigen epitopes are incorporated in a proprietary formulation designed to maximize mRNA delivery and minimize mRNA-triggered immune responses. Upon administration, the mRNA-based PCV NCI-4650 is taken up and the mRNAs are translated by antigen presenting cells (APCs). Then, the expressed epitopes are presented via major histocompatibility complex (MHC) molecules on the surface of the APCs. This induces both cytotoxic T-lymphocyte (CTL)- and memory T-cell-dependent immune responses that specifically target and destroy the patient's cancer cells that express these neoantigens." @default.
- NCIT_C148239 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148239 NCIT_NHC0 "C148239" @default.
- NCIT_C148239 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148239 NCIT_P107 "mRNA-based Personalized Cancer Vaccine NCI-4650" @default.
- NCIT_C148239 NCIT_P108 "mRNA-based Personalized Cancer Vaccine NCI-4650" @default.
- NCIT_C148239 NCIT_P208 "CL550832" @default.
- NCIT_C148239 NCIT_P322 "CTRP" @default.
- NCIT_C148239 NCIT_P322 "GDC" @default.
- NCIT_C148239 NCIT_P329 "795447" @default.
- NCIT_C148239 NCIT_P330 "795447" @default.
- NCIT_C148239 NCIT_P375 "mRNA-based Personalized Cancer Vaccine NCI-4650" @default.
- NCIT_C148239 NCIT_P399 "795447" @default.
- NCIT_C148239 normalizedInformationContent "100" @default.
- NCIT_C148239 referenceCount "1" @default.
- NCIT_C148239 hasExactSynonym "NCI 4650" @default.
- NCIT_C148239 hasExactSynonym "NCI-4650" @default.
- NCIT_C148239 hasExactSynonym "mRNA-based PCV NCI-4650" @default.
- NCIT_C148239 hasExactSynonym "mRNA-based Personalized Cancer Vaccine NCI-4650" @default.
- NCIT_C148239 inSubset NCIT_C116977 @default.
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- NCIT_C148239 inSubset NCIT_C128784 @default.
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- NCIT_C148239 inSubset NCIT_C176424 @default.
- NCIT_C148239 inSubset NCIT_C177537 @default.
- NCIT_C148239 type Class @default.
- NCIT_C148239 isDefinedBy ncit.owl @default.
- NCIT_C148239 label "mRNA-based Personalized Cancer Vaccine NCI-4650" @default.
- NCIT_C148239 subClassOf NCIT_C129820 @default.
- NCIT_C148239 subClassOf NCIT_C148239 @default.
- NCIT_C148239 subClassOf NCIT_C1663 @default.
- NCIT_C148239 subClassOf NCIT_C172787 @default.
- NCIT_C148239 subClassOf NCIT_C181141 @default.
- NCIT_C148239 subClassOf NCIT_C1908 @default.
- NCIT_C148239 subClassOf NCIT_C1909 @default.
- NCIT_C148239 subClassOf NCIT_C274 @default.
- NCIT_C148239 subClassOf NCIT_C307 @default.
- NCIT_C148239 subClassOf NCIT_C308 @default.
- NCIT_C148239 subClassOf NCIT_C923 @default.