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- NCIT_C148267 IAO_0000115 "A controlled-release tablet formulation containing the hydrochloride salt of the aminoketone bupropion, with antidepressant activity and for potential use in promoting smoking cessation, improving sexual desire, and improving cancer-related fatigue. Bupropion is a weak blocker of the neuronal uptake of serotonin, dopamine and norepinephrine and is a central nicotinic acetylcholine receptor antagonist. Bupropion may also reduce circulating levels of tumor necrosis factor (TNF) and normalize hypothalamic-pituitary-adrenal (HPA) axis functioning, which is dysregulated in certain cases of cancer-related fatigue. The controlled-release formulation results in a higher concentration of the drug in the body over an extended period, thereby permitting a reduction in the frequency of dosing." @default.
- NCIT_C148267 NCIT_A6 NCIT_C62012 @default.
- NCIT_C148267 NCIT_NHC0 "C148267" @default.
- NCIT_C148267 NCIT_P106 "Organic Chemical" @default.
- NCIT_C148267 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148267 NCIT_P107 "Bupropion Hydrochloride Controlled-release" @default.
- NCIT_C148267 NCIT_P108 "Bupropion Hydrochloride Controlled-release" @default.
- NCIT_C148267 NCIT_P208 "CL550923" @default.
- NCIT_C148267 NCIT_P322 "CTRP" @default.
- NCIT_C148267 NCIT_P329 "792878" @default.
- NCIT_C148267 NCIT_P330 "792878" @default.
- NCIT_C148267 NCIT_P399 "792878" @default.
- NCIT_C148267 NCIT_R122 NCIT_C16484 @default.
- NCIT_C148267 NCIT_R122 NCIT_C16486 @default.
- NCIT_C148267 NCIT_R122 NCIT_C16554 @default.
- NCIT_C148267 NCIT_R122 NCIT_C16865 @default.
- NCIT_C148267 NCIT_R122 NCIT_C16946 @default.
- NCIT_C148267 NCIT_R122 NCIT_C17021 @default.
- NCIT_C148267 NCIT_R122 NCIT_C20027 @default.
- NCIT_C148267 NCIT_R122 NCIT_C26548 @default.
- NCIT_C148267 NCIT_R122 NCIT_C28459 @default.
- NCIT_C148267 NCIT_R122 NCIT_C40050 @default.
- NCIT_C148267 normalizedInformationContent "100" @default.
- NCIT_C148267 referenceCount "1" @default.
- NCIT_C148267 hasExactSynonym "Bupropion HCl Controlled-release" @default.
- NCIT_C148267 hasExactSynonym "Bupropion HCl Extended Release" @default.
- NCIT_C148267 hasExactSynonym "Bupropion Hydrochloride Controlled-release" @default.
- NCIT_C148267 hasExactSynonym "Bupropion Hydrochloride Extended-Release" @default.
- NCIT_C148267 hasExactSynonym "Forfivo XL" @default.
- NCIT_C148267 hasExactSynonym "Wellbutrin SR" @default.
- NCIT_C148267 hasExactSynonym "Wellbutrin XL" @default.
- NCIT_C148267 hasExactSynonym "Zyban" @default.
- NCIT_C148267 inSubset NCIT_C116977 @default.
- NCIT_C148267 inSubset NCIT_C116978 @default.
- NCIT_C148267 inSubset NCIT_C176424 @default.
- NCIT_C148267 type Class @default.
- NCIT_C148267 isDefinedBy ncit.owl @default.
- NCIT_C148267 label "Bupropion Hydrochloride Controlled-release" @default.
- NCIT_C148267 subClassOf B1a21d4573f560c97a8b9c614f4358cd3 @default.
- NCIT_C148267 subClassOf B92e70403b8f9374ecae7968e23cb35f5 @default.
- NCIT_C148267 subClassOf NCIT_C148267 @default.
- NCIT_C148267 subClassOf NCIT_C1908 @default.
- NCIT_C148267 subClassOf NCIT_C1909 @default.
- NCIT_C148267 subClassOf NCIT_C265 @default.
- NCIT_C148267 subClassOf NCIT_C78272 @default.