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- NCIT_C148276 IAO_0000115 "A lipophilic phosphonamidate prodrug of tenofovir, a synthetic antiviral acyclic nucleotide analog of adenosine 5-monophosphate and a nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity against hepatitis B virus (HBV) and potentially against human immunodeficiency virus (HIV). Upon oral administration, tenofovir alafenamide is taken up by hepatocytes through passive diffusion and through the hepatic uptake transporters organic anion transporting polypeptides 1B1 (OATP1B1) and 1B3 (OATP1B3). Inside the hepatocytes, tenofovir alafenamide is hydrolyzed and converted to tenofovir by carboxylesterase 1 (CES1). Intracellular tenofovir is phosphorylated by cellular kinases to its pharmacologically active form, tenofovir diphosphate. Tenofovir diphosphate is incorporated into viral DNA instead of the natural substrate deoxyadenosine 5-triphosphate, and inhibits HBV reverse transcriptase, resulting in DNA chain-termination and inhibition of HBV replication. In addition, tenofovir diphosphate is incorporated into HIV DNA instead of the natural substrate deoxyadenosine 5-triphosphate, thereby inhibiting HIV-1 reverse transcriptase (RT) and resulting in DNA chain termination and impairment of HIV replication." @default.
- NCIT_C148276 NCIT_NHC0 "C148276" @default.
- NCIT_C148276 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C148276 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148276 NCIT_P107 "Tenofovir Alafenamide" @default.
- NCIT_C148276 NCIT_P108 "Tenofovir Alafenamide" @default.
- NCIT_C148276 NCIT_P208 "CL550911" @default.
- NCIT_C148276 NCIT_P210 "379270-37-8" @default.
- NCIT_C148276 NCIT_P319 "EL9943AG5J" @default.
- NCIT_C148276 NCIT_P322 "CTRP" @default.
- NCIT_C148276 NCIT_P322 "FDA" @default.
- NCIT_C148276 NCIT_P399 "804699" @default.
- NCIT_C148276 normalizedInformationContent "100" @default.
- NCIT_C148276 referenceCount "1" @default.
- NCIT_C148276 hasExactSynonym "GS 7340" @default.
- NCIT_C148276 hasExactSynonym "GS-7340" @default.
- NCIT_C148276 hasExactSynonym "L-Alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-Methylethyl Ester" @default.
- NCIT_C148276 hasExactSynonym "TENOFOVIR ALAFENAMIDE" @default.
- NCIT_C148276 hasExactSynonym "TFV Alafenamide" @default.
- NCIT_C148276 hasExactSynonym "Tenofovir Alafenamide" @default.
- NCIT_C148276 inSubset NCIT_C116977 @default.
- NCIT_C148276 inSubset NCIT_C116978 @default.
- NCIT_C148276 inSubset NCIT_C176424 @default.
- NCIT_C148276 inSubset NCIT_C63923 @default.
- NCIT_C148276 type Class @default.
- NCIT_C148276 isDefinedBy ncit.owl @default.
- NCIT_C148276 label "Tenofovir Alafenamide" @default.
- NCIT_C148276 subClassOf NCIT_C148276 @default.
- NCIT_C148276 subClassOf NCIT_C1589 @default.
- NCIT_C148276 subClassOf NCIT_C1908 @default.
- NCIT_C148276 subClassOf NCIT_C1909 @default.
- NCIT_C148276 subClassOf NCIT_C254 @default.
- NCIT_C148276 subClassOf NCIT_C281 @default.
- NCIT_C148276 subClassOf NCIT_C471 @default.
- NCIT_C148276 subClassOf NCIT_C97452 @default.