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- NCIT_C148289 IAO_0000115 "A formulation composed of an agonist of toll-like receptor (TLR) type 7 and 8 (TLR7/8) that is attached to polyethylene glycol (PEG) via a hydrolyzable glycine linker, with potential immunostimulating and antitumor activities. Upon intratumoral (IT) administration, TLR7/8 agonist NKTR-262 binds to and activates TLR7 and 8, thereby activating TLR7/8-mediated pathways. This stimulates the maturation and activation of antigen-presenting cells (APCs), including dendritic cells (DCs). Activation of DCs results in the production of pro-inflammatory cytokines, and the activation of cytotoxic T-lymphocyte (CTL)- and B-lymphocyte-mediated immune responses against tumor-associated antigens (TAAs), which lead to tumor cell lysis. TLR7 and 8, members of the TLR family, play fundamental roles in the activation of the innate immune system, myeloid cell responses and tumor antigen presentation. Pegylation of the TLR7/8 agonist enhances retention of this agent in the tumor microenvironment (TME), provides local sustained release of the TLR7/8 agonist, increases efficacy and reduces systemic exposure compared to the administration of the naked TLR7/8 agonist alone." @default.
- NCIT_C148289 NCIT_A7 NCIT_C30108 @default.
- NCIT_C148289 NCIT_A7 NCIT_C30109 @default.
- NCIT_C148289 NCIT_NHC0 "C148289" @default.
- NCIT_C148289 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148289 NCIT_P107 "PEG-conjugated TLR7/8 Agonist NKTR-262" @default.
- NCIT_C148289 NCIT_P108 "PEG-conjugated TLR7/8 Agonist NKTR-262" @default.
- NCIT_C148289 NCIT_P208 "CL550901" @default.
- NCIT_C148289 NCIT_P322 "CTRP" @default.
- NCIT_C148289 NCIT_P329 "795599" @default.
- NCIT_C148289 NCIT_P330 "795599" @default.
- NCIT_C148289 NCIT_P399 "795599" @default.
- NCIT_C148289 normalizedInformationContent "100" @default.
- NCIT_C148289 referenceCount "1" @default.
- NCIT_C148289 hasExactSynonym "NKTR 262" @default.
- NCIT_C148289 hasExactSynonym "NKTR-262" @default.
- NCIT_C148289 hasExactSynonym "NKTR262" @default.
- NCIT_C148289 hasExactSynonym "PEG-conjugated TLR7/8 Agonist NKTR-262" @default.
- NCIT_C148289 hasExactSynonym "TLR 7/8 Agonist NKTR-262" @default.
- NCIT_C148289 hasExactSynonym "TLR7/TLR8 Agonist NKTR-262" @default.
- NCIT_C148289 hasExactSynonym "Toll-like Receptor 7/8 Agonist NKTR-262" @default.
- NCIT_C148289 inSubset NCIT_C116977 @default.
- NCIT_C148289 inSubset NCIT_C116978 @default.
- NCIT_C148289 inSubset NCIT_C176424 @default.
- NCIT_C148289 type Class @default.
- NCIT_C148289 isDefinedBy ncit.owl @default.
- NCIT_C148289 label "PEG-conjugated TLR7/8 Agonist NKTR-262" @default.
- NCIT_C148289 subClassOf NCIT_C148289 @default.
- NCIT_C148289 subClassOf NCIT_C177174 @default.
- NCIT_C148289 subClassOf NCIT_C177176 @default.
- NCIT_C148289 subClassOf NCIT_C177177 @default.
- NCIT_C148289 subClassOf NCIT_C1908 @default.
- NCIT_C148289 subClassOf NCIT_C1909 @default.
- NCIT_C148289 subClassOf NCIT_C2139 @default.
- NCIT_C148289 subClassOf NCIT_C308 @default.