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- NCIT_C148402 IAO_0000115 "A cancer vaccine consisting of a recombinant fowlpox viral (FPV) vector encoding the human transcription factor and tumor-associated antigen (TAA) brachyury, and a triad of T-cell co-stimulatory molecules (TRICOM), which is comprised of the three human immune-enhancing co-stimulatory molecules B7-1, ICAM-1 and LFA-3, with potential immunostimulatory and antineoplastic activities. Upon subcutaneous administration occurring after the administration of a proprietary modified vaccinia Ankara developed by Bavarian Nordic-based prime vaccine (MVA-BN-brachyury), the booster vaccine FPV-brachyury vaccine potentiates a cytotoxic T-lymphocyte (CTL) response against brachyury-expressing tumor cells. The expression of brachyury, a member of the T-box family of transcription factors that is overexpressed in numerous cancer cell types, is correlated with increased epithelial-mesenchymal transition (EMT), cancer resistance, cancer progression and metastasis. TRICOM enhances antigen-specific T-cell activation." @default.
- NCIT_C148402 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148402 NCIT_A7 NCIT_C84458 @default.
- NCIT_C148402 NCIT_NHC0 "C148402" @default.
- NCIT_C148402 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148402 NCIT_P106 "Virus" @default.
- NCIT_C148402 NCIT_P107 "FPV-Brachyury-TRICOM Vaccine" @default.
- NCIT_C148402 NCIT_P108 "FPV-Brachyury-TRICOM Vaccine" @default.
- NCIT_C148402 NCIT_P208 "CL551011" @default.
- NCIT_C148402 NCIT_P322 "CTRP" @default.
- NCIT_C148402 NCIT_P322 "GDC" @default.
- NCIT_C148402 NCIT_P375 "FPV-Brachyury-TRICOM Vaccine" @default.
- NCIT_C148402 normalizedInformationContent "100" @default.
- NCIT_C148402 referenceCount "1" @default.
- NCIT_C148402 hasExactSynonym "FPV-Brachyury Boost Vaccine" @default.
- NCIT_C148402 hasExactSynonym "FPV-Brachyury" @default.
- NCIT_C148402 hasExactSynonym "FPV-Brachyury-TRICOM Vaccine" @default.
- NCIT_C148402 inSubset NCIT_C116977 @default.
- NCIT_C148402 inSubset NCIT_C116978 @default.
- NCIT_C148402 inSubset NCIT_C128784 @default.
- NCIT_C148402 inSubset NCIT_C157711 @default.
- NCIT_C148402 inSubset NCIT_C157712 @default.
- NCIT_C148402 inSubset NCIT_C177537 @default.
- NCIT_C148402 type Class @default.
- NCIT_C148402 isDefinedBy ncit.owl @default.
- NCIT_C148402 label "FPV-Brachyury-TRICOM Vaccine" @default.
- NCIT_C148402 subClassOf NCIT_C148402 @default.
- NCIT_C148402 subClassOf NCIT_C1572 @default.
- NCIT_C148402 subClassOf NCIT_C1908 @default.
- NCIT_C148402 subClassOf NCIT_C1909 @default.
- NCIT_C148402 subClassOf NCIT_C2521 @default.
- NCIT_C148402 subClassOf NCIT_C307 @default.
- NCIT_C148402 subClassOf NCIT_C308 @default.
- NCIT_C148402 subClassOf NCIT_C923 @default.
- NCIT_C148402 subClassOf NCIT_C96404 @default.