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- NCIT_C148408 IAO_0000115 "The sodium salt form of dolutegravir, an orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication." @default.
- NCIT_C148408 NCIT_A6 NCIT_C121543 @default.
- NCIT_C148408 NCIT_NHC0 "C148408" @default.
- NCIT_C148408 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148408 NCIT_P108 "Dolutegravir Sodium" @default.
- NCIT_C148408 NCIT_P208 "CL551002" @default.
- NCIT_C148408 NCIT_P210 "1051375-19-9" @default.
- NCIT_C148408 NCIT_P319 "1Q1V9V5WYQ" @default.
- NCIT_C148408 NCIT_P322 "FDA" @default.
- NCIT_C148408 normalizedInformationContent "100" @default.
- NCIT_C148408 referenceCount "1" @default.
- NCIT_C148408 hasExactSynonym "DOLUTEGRAVIR SODIUM" @default.
- NCIT_C148408 hasExactSynonym "Dolutegravir Sodium" @default.
- NCIT_C148408 hasExactSynonym "Tivicay" @default.
- NCIT_C148408 inSubset NCIT_C63923 @default.
- NCIT_C148408 type Class @default.
- NCIT_C148408 isDefinedBy ncit.owl @default.
- NCIT_C148408 label "Dolutegravir Sodium" @default.
- NCIT_C148408 subClassOf NCIT_C148408 @default.
- NCIT_C148408 subClassOf NCIT_C157401 @default.
- NCIT_C148408 subClassOf NCIT_C1660 @default.
- NCIT_C148408 subClassOf NCIT_C1908 @default.
- NCIT_C148408 subClassOf NCIT_C1909 @default.
- NCIT_C148408 subClassOf NCIT_C254 @default.
- NCIT_C148408 subClassOf NCIT_C281 @default.