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- NCIT_C148416 IAO_0000115 "A fusion protein composed of CD40 ligand (CD40L; CD154; TRAP; TNFSF5) fused to a modified immunoglobulin (Ig) Fc fragment, with potential immunostimulating activity. Upon administration of the CD40L-Fc fusion protein MEDI5083, the CD40L moiety specifically targets, binds to, and activates CD40, a cell surface receptor that belongs to the tumor necrosis factor (TNF) receptor family and is expressed on various immune cells, such as B-lymphocytes, monocytes, and dendritic cells (DCs). Activation of CD40 induces proliferation and activation of B-lymphocytes, shifts the induction of suppressive macrophages towards immunostimulatory macrophages, activates monocyte-derived DCs (moDCs), and leads to the secretion of inflammatory cytokines, which activates the immune system to induce the proliferation and activation of cytotoxic T-lymphocytes (CTLs) against tumor cells. Altogether, this may cause tumor cell lysis." @default.
- NCIT_C148416 NCIT_A7 NCIT_C17281 @default.
- NCIT_C148416 NCIT_NHC0 "C148416" @default.
- NCIT_C148416 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148416 NCIT_P107 "CD40L-Fc Fusion Protein MEDI5083" @default.
- NCIT_C148416 NCIT_P108 "CD40L-Fc Fusion Protein MEDI5083" @default.
- NCIT_C148416 NCIT_P208 "CL550995" @default.
- NCIT_C148416 NCIT_P319 "IF0TRZ2MZ3" @default.
- NCIT_C148416 NCIT_P322 "CTRP" @default.
- NCIT_C148416 NCIT_P322 "FDA" @default.
- NCIT_C148416 NCIT_P329 "792628" @default.
- NCIT_C148416 NCIT_P330 "792628" @default.
- NCIT_C148416 NCIT_P399 "792628" @default.
- NCIT_C148416 normalizedInformationContent "100" @default.
- NCIT_C148416 referenceCount "1" @default.
- NCIT_C148416 hasExactSynonym "CD40L-Fc Fusion Protein MEDI5083" @default.
- NCIT_C148416 hasExactSynonym "MEDI 5083" @default.
- NCIT_C148416 hasExactSynonym "MEDI-5083" @default.
- NCIT_C148416 hasExactSynonym "MEDI5083" @default.
- NCIT_C148416 inSubset NCIT_C116977 @default.
- NCIT_C148416 inSubset NCIT_C116978 @default.
- NCIT_C148416 inSubset NCIT_C176424 @default.
- NCIT_C148416 inSubset NCIT_C63923 @default.
- NCIT_C148416 type Class @default.
- NCIT_C148416 isDefinedBy ncit.owl @default.
- NCIT_C148416 label "CD40L-Fc Fusion Protein MEDI5083" @default.
- NCIT_C148416 subClassOf NCIT_C1283 @default.
- NCIT_C148416 subClassOf NCIT_C148416 @default.
- NCIT_C148416 subClassOf NCIT_C1908 @default.
- NCIT_C148416 subClassOf NCIT_C1909 @default.
- NCIT_C148416 subClassOf NCIT_C1941 @default.
- NCIT_C148416 subClassOf NCIT_C307 @default.
- NCIT_C148416 subClassOf NCIT_C308 @default.