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- NCIT_C148455 IAO_0000115 "An orally bioavailable, reversible inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4), with potential antineoplastic, immunomodulating and anti-inflammatory activities. Upon oral administration, emavusertib targets, binds to, and blocks the kinase activity of IRAK4. This inhibits IRAK4-mediated signaling, prevents the activation of IRAK4-mediated nuclear factor-kappa B (NF-kB) signaling and decreases the expression of inflammatory cytokines and certain pro-survival factors. This inhibits proliferation of IRAK4-overactivated tumor cells, which are found in cells harboring MYD88 activating mutations or those with overactivated toll-like receptor (TLR) pathways. In addition, CA-4948 may inhibit inflammation and immune-mediated cell destruction in inflammatory and auto-immune diseases where TLR or interleukin 1 receptor (IL-1R) signaling is overactivated and MYD88 is dysregulated. IRAK4, a serine/threonine-protein kinase that plays a key role in both the TLR and IL-1R signaling pathways, is activated though the adaptor protein MYD88 and links the TLR and IL-1R signaling pathway to the NF-kB pathway." @default.
- NCIT_C148455 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148455 NCIT_A5 NCIT_C189979 @default.
- NCIT_C148455 NCIT_A7 NCIT_C29752 @default.
- NCIT_C148455 NCIT_NHC0 "C148455" @default.
- NCIT_C148455 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148455 NCIT_P107 "Emavusertib" @default.
- NCIT_C148455 NCIT_P108 "Emavusertib" @default.
- NCIT_C148455 NCIT_P208 "CL551081" @default.
- NCIT_C148455 NCIT_P210 "1801343-74-7" @default.
- NCIT_C148455 NCIT_P319 "MH5DMF9JKY" @default.
- NCIT_C148455 NCIT_P322 "CTRP" @default.
- NCIT_C148455 NCIT_P322 "FDA" @default.
- NCIT_C148455 NCIT_P322 "GDC" @default.
- NCIT_C148455 NCIT_P329 "794871" @default.
- NCIT_C148455 NCIT_P330 "794871" @default.
- NCIT_C148455 NCIT_P375 "IRAK4 Inhibitor CA-4948" @default.
- NCIT_C148455 NCIT_P399 "794871" @default.
- NCIT_C148455 normalizedInformationContent "100" @default.
- NCIT_C148455 referenceCount "1" @default.
- NCIT_C148455 hasExactSynonym "AU 4948" @default.
- NCIT_C148455 hasExactSynonym "AU-4948" @default.
- NCIT_C148455 hasExactSynonym "CA 4948" @default.
- NCIT_C148455 hasExactSynonym "CA-4948" @default.
- NCIT_C148455 hasExactSynonym "CA4948" @default.
- NCIT_C148455 hasExactSynonym "EMAVUSERTIB" @default.
- NCIT_C148455 hasExactSynonym "Emavusertib" @default.
- NCIT_C148455 hasExactSynonym "IRAK4 Inhibitor CA-4948" @default.
- NCIT_C148455 hasExactSynonym "Interleukin-1 Receptor-associated Kinase 4 Inhibitor CA-4948" @default.
- NCIT_C148455 inSubset NCIT_C116977 @default.
- NCIT_C148455 inSubset NCIT_C116978 @default.
- NCIT_C148455 inSubset NCIT_C157711 @default.
- NCIT_C148455 inSubset NCIT_C157712 @default.
- NCIT_C148455 inSubset NCIT_C176424 @default.
- NCIT_C148455 inSubset NCIT_C177537 @default.
- NCIT_C148455 inSubset NCIT_C63923 @default.
- NCIT_C148455 type Class @default.
- NCIT_C148455 isDefinedBy ncit.owl @default.
- NCIT_C148455 label "Emavusertib" @default.
- NCIT_C148455 subClassOf NCIT_C129820 @default.
- NCIT_C148455 subClassOf NCIT_C1404 @default.
- NCIT_C148455 subClassOf NCIT_C148455 @default.
- NCIT_C148455 subClassOf NCIT_C184956 @default.
- NCIT_C148455 subClassOf NCIT_C1908 @default.
- NCIT_C148455 subClassOf NCIT_C1909 @default.
- NCIT_C148455 subClassOf NCIT_C274 @default.
- NCIT_C148455 subClassOf NCIT_C308 @default.
- NCIT_C148455 subClassOf NCIT_C471 @default.
- NCIT_C148455 subClassOf NCIT_C61074 @default.