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- NCIT_C148488 IAO_0000115 "A Bcl-2 homology (BH)-3 mimetic and selective inhibitor of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL, with potential pro-apoptotic and antineoplastic activities. Upon administration, pelcitoclax specifically binds to and inhibits the activity of the pro-survival proteins Bcl-2 and Bcl-XL. This restores apoptotic processes and inhibits cell proliferation in Bcl-2/Bcl-XL-dependent tumor cells. Bcl-2 and Bcl-XL, proteins belonging to the Bcl-2 family that are overexpressed in many cancers, play an important role in the negative regulation of apoptosis; tumor expression is associated with increased drug resistance and cancer cell survival." @default.
- NCIT_C148488 NCIT_A7 NCIT_C17698 @default.
- NCIT_C148488 NCIT_A7 NCIT_C18115 @default.
- NCIT_C148488 NCIT_NHC0 "C148488" @default.
- NCIT_C148488 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148488 NCIT_P107 "Pelcitoclax" @default.
- NCIT_C148488 NCIT_P108 "Pelcitoclax" @default.
- NCIT_C148488 NCIT_P208 "CL551057" @default.
- NCIT_C148488 NCIT_P210 "1619923-36-2" @default.
- NCIT_C148488 NCIT_P319 "317UBD60ML" @default.
- NCIT_C148488 NCIT_P322 "CTRP" @default.
- NCIT_C148488 NCIT_P322 "FDA" @default.
- NCIT_C148488 NCIT_P329 "792573" @default.
- NCIT_C148488 NCIT_P330 "792573" @default.
- NCIT_C148488 NCIT_P399 "792573" @default.
- NCIT_C148488 normalizedInformationContent "100" @default.
- NCIT_C148488 referenceCount "1" @default.
- NCIT_C148488 hasExactSynonym "APG 1252" @default.
- NCIT_C148488 hasExactSynonym "APG-1252" @default.
- NCIT_C148488 hasExactSynonym "APG1252" @default.
- NCIT_C148488 hasExactSynonym "Bcl-2/Bcl-XL Inhibitor APG-1252" @default.
- NCIT_C148488 hasExactSynonym "PELCITOCLAX" @default.
- NCIT_C148488 hasExactSynonym "Pelcitoclax" @default.
- NCIT_C148488 inSubset NCIT_C116977 @default.
- NCIT_C148488 inSubset NCIT_C116978 @default.
- NCIT_C148488 inSubset NCIT_C176424 @default.
- NCIT_C148488 inSubset NCIT_C63923 @default.
- NCIT_C148488 type Class @default.
- NCIT_C148488 isDefinedBy ncit.owl @default.
- NCIT_C148488 label "Pelcitoclax" @default.
- NCIT_C148488 subClassOf NCIT_C129839 @default.
- NCIT_C148488 subClassOf NCIT_C148488 @default.
- NCIT_C148488 subClassOf NCIT_C159200 @default.
- NCIT_C148488 subClassOf NCIT_C163758 @default.
- NCIT_C148488 subClassOf NCIT_C1908 @default.
- NCIT_C148488 subClassOf NCIT_C1909 @default.
- NCIT_C148488 subClassOf NCIT_C192025 @default.
- NCIT_C148488 subClassOf NCIT_C274 @default.