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- NCIT_C148498 IAO_0000115 "A preparation of autologous T-lymphocytes that are transduced, ex vivo, with LCAR-B38M, a lentiviral vector expressing a chimeric antigen receptor (CAR) containing two bispecific anti-B-cell maturation antigen (BCMA) variable fragments of llama heavy-chain murine antibodies fused to the signaling domain of 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. The antigen-binding region of the CAR is a non-scFv structure targeting two distinct regions of BCMA. Upon intravenous administration back into the patient, ciltacabtagene autoleucel are directed to cells expressing BCMA, bind to two different epitopes on BCMA and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-associated antigen (TAA) and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is overexpressed on malignant plasma cells." @default.
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- NCIT_C148498 NCIT_P107 "Ciltacabtagene Autoleucel" @default.
- NCIT_C148498 NCIT_P108 "Ciltacabtagene Autoleucel" @default.
- NCIT_C148498 NCIT_P208 "CL551044" @default.
- NCIT_C148498 NCIT_P302 "the treatment of adult patients with relapsed or refractory multiple myeloma" @default.
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- NCIT_C148498 NCIT_P375 "Autologous Bi-epitope BCMA-targeted CAR T-cells JNJ-68284528" @default.
- NCIT_C148498 NCIT_P375 "Ciltacabtagene Autoleucel" @default.
- NCIT_C148498 NCIT_P399 "792630" @default.
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- NCIT_C148498 hasExactSynonym "Autologous Anti-BCMA CAR-T Cells JNJ-68284528" @default.
- NCIT_C148498 hasExactSynonym "Autologous Bi-epitope BCMA-targeted CAR T-cells JNJ-68284528" @default.
- NCIT_C148498 hasExactSynonym "Autologous Bi-epitope CAR T-cells JNJ-68284528" @default.
- NCIT_C148498 hasExactSynonym "CARVYKTI" @default.
- NCIT_C148498 hasExactSynonym "CILTACABTAGENE AUTOLEUCEL" @default.
- NCIT_C148498 hasExactSynonym "Cilta-cel" @default.
- NCIT_C148498 hasExactSynonym "Ciltacabtagene Autoleucel" @default.
- NCIT_C148498 hasExactSynonym "JNJ-68284528" @default.
- NCIT_C148498 hasExactSynonym "LCAR-B38M" @default.
- NCIT_C148498 hasExactSynonym "LCAR-B38M-transduced CAR-T Cells JNJ-68284528" @default.
- NCIT_C148498 hasExactSynonym "LCAR-B38M-transduced Car-T Cells JNJ-68284528" @default.
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- NCIT_C148498 type Class @default.
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- NCIT_C148498 label "Ciltacabtagene Autoleucel" @default.
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