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- NCIT_C148500 IAO_0000115 "A preparation of allogeneic, donor-derived T-lymphocytes that are specific for a unique set of minor histocompatibility complex antigens (MiHA) exclusively found on the surface of malignant cells, with potential immunomodulating and antineoplastic activities. T-lymphocytes are derived from an allogeneic hematopoietic cell transplant (AHCT) donor. Ex vivo, these T-cells are exposed to and primed against a select set of host-specific hematopoietic tissue-restricted MiHAs that are expressed on leukemic cells. Then the cells are subsequently expanded. After AHCT and infusion of the anti-MiHA T-lymphocytes, these cells target and bind to MiHA antigens expressed on the host's leukemia cells, thereby killing these cancer cells. MiHA are small, cell-surface peptides that are associated with graft-versus-host disease (GvHD). The selected set of MiHAs is expressed mainly, or only, by hematopoietic cells, and overexpressed on leukemic cells." @default.
- NCIT_C148500 NCIT_NHC0 "C148500" @default.
- NCIT_C148500 NCIT_P106 "Cell" @default.
- NCIT_C148500 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148500 NCIT_P108 "Anti-minor Histocompatibility Complex Donor T-Lymphocytes" @default.
- NCIT_C148500 NCIT_P208 "CL552436" @default.
- NCIT_C148500 NCIT_P329 "792634" @default.
- NCIT_C148500 NCIT_P330 "792634" @default.
- NCIT_C148500 NCIT_P399 "792634" @default.
- NCIT_C148500 normalizedInformationContent "100" @default.
- NCIT_C148500 referenceCount "1" @default.
- NCIT_C148500 hasExactSynonym "Anti-MiHA Donor T-lymphocytes" @default.
- NCIT_C148500 hasExactSynonym "Anti-MiHA T Cells" @default.
- NCIT_C148500 hasExactSynonym "Anti-minor Histocompatibility Complex Donor T-Lymphocytes" @default.
- NCIT_C148500 hasExactSynonym "GLIDE Cells" @default.
- NCIT_C148500 hasExactSynonym "GLIDE T-lymphocytes" @default.
- NCIT_C148500 hasExactSynonym "GLIDE" @default.
- NCIT_C148500 hasExactSynonym "Guided Lymphocyte Immunopeptide Derived Expansion Against MiHAs Cells" @default.
- NCIT_C148500 hasExactSynonym "Guided Lymphocyte Immunopeptide Derived Expansion Cells" @default.
- NCIT_C148500 hasExactSynonym "MiHA T-lympocytes" @default.
- NCIT_C148500 hasExactSynonym "MiHA-specific T Cells" @default.
- NCIT_C148500 inSubset NCIT_C128784 @default.
- NCIT_C148500 inSubset NCIT_C176424 @default.
- NCIT_C148500 type Class @default.
- NCIT_C148500 isDefinedBy ncit.owl @default.
- NCIT_C148500 label "Anti-minor Histocompatibility Complex Donor T-Lymphocytes" @default.
- NCIT_C148500 subClassOf NCIT_C129820 @default.
- NCIT_C148500 subClassOf NCIT_C129821 @default.
- NCIT_C148500 subClassOf NCIT_C129826 @default.
- NCIT_C148500 subClassOf NCIT_C142078 @default.
- NCIT_C148500 subClassOf NCIT_C148500 @default.
- NCIT_C148500 subClassOf NCIT_C1908 @default.
- NCIT_C148500 subClassOf NCIT_C1909 @default.
- NCIT_C148500 subClassOf NCIT_C274 @default.
- NCIT_C148500 subClassOf NCIT_C28676 @default.
- NCIT_C148500 subClassOf NCIT_C307 @default.
- NCIT_C148500 subClassOf NCIT_C308 @default.