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- NCIT_C148521 IAO_0000115 "A recombinant form of a toxic protein derived from the salivary glands of the Amblyomma cajennense tick that inhibits Factor Xa and induces apoptosis, with potential antithrombotic and antineoplastic activities. Upon administration, amblyomin-X promotes endoplasmic reticulum (ER) stress, mitochondrial dysfunction, cytochrome-c release, poly(ADP-ribose) polymerase (PARP) cleavage, and activation of caspase. Additionally, this agent selectively induces apoptosis in tumor cells. It also affects endothelial cell functions, such as adhesion, and may inhibit angiogenesis. Amblyomin-X targets and binds to factor Xa, inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development. As cancer is associated with thrombosis, amblyomin-X could potentially exert its antineoplastic and antithrombotic effects in the cancer patient at the same time." @default.
- NCIT_C148521 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148521 NCIT_NHC0 "C148521" @default.
- NCIT_C148521 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148521 NCIT_P108 "Amblyomin-X" @default.
- NCIT_C148521 NCIT_P208 "CL551143" @default.
- NCIT_C148521 NCIT_P322 "GDC" @default.
- NCIT_C148521 NCIT_P329 "792680" @default.
- NCIT_C148521 NCIT_P330 "792680" @default.
- NCIT_C148521 NCIT_P375 "Amblyomin-X" @default.
- NCIT_C148521 NCIT_P399 "792680" @default.
- NCIT_C148521 normalizedInformationContent "100" @default.
- NCIT_C148521 referenceCount "1" @default.
- NCIT_C148521 hasExactSynonym "Amblyomin-X" @default.
- NCIT_C148521 inSubset NCIT_C128784 @default.
- NCIT_C148521 inSubset NCIT_C157711 @default.
- NCIT_C148521 inSubset NCIT_C157712 @default.
- NCIT_C148521 inSubset NCIT_C176424 @default.
- NCIT_C148521 inSubset NCIT_C177537 @default.
- NCIT_C148521 type Class @default.
- NCIT_C148521 isDefinedBy ncit.owl @default.
- NCIT_C148521 label "Amblyomin-X" @default.
- NCIT_C148521 subClassOf NCIT_C129839 @default.
- NCIT_C148521 subClassOf NCIT_C148521 @default.
- NCIT_C148521 subClassOf NCIT_C1908 @default.
- NCIT_C148521 subClassOf NCIT_C1909 @default.
- NCIT_C148521 subClassOf NCIT_C263 @default.
- NCIT_C148521 subClassOf NCIT_C274 @default.
- NCIT_C148521 subClassOf NCIT_C78275 @default.