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- NCIT_C148531 IAO_0000115 "A nanoparticle-based formulation consisting of polymeric micelles encapsulating the taxane paclitaxel, with potential antineoplastic activity. Paclitaxel is covalently bound to polyethylene glycol (PEG)-based block copolymers which forms a micellar structure with an outer hydrophilic PEG shell surrounding the hydrophobic paclitaxel. Upon administration of the paclitaxel polymeric micelle formulation NANT-008, the nanoparticles are stable in the bloodstream and specifically accumulate in the tumor tissue. Due to the acidic conditions in the tumor and the pH-responsive nature of the micelles, paclitaxel is released in the tumor environment. Paclitaxel binds to microtubules, promotes microtubule assembly, and prevents depolymerization, thus interfering with normal mitosis. Compared to the administration of paclitaxel alone, this formulation increases the solubility of paclitaxel, enhances its specific retention in cancer tissue, and increases its therapeutic effect, while decreasing its toxicity. In addition, the micellar formulation allows the delivery of higher doses of paclitaxel to target tissues while minimizing systemic toxicity." @default.
- NCIT_C148531 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148531 NCIT_NHC0 "C148531" @default.
- NCIT_C148531 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148531 NCIT_P108 "Paclitaxel Polymeric Micelle Formulation NANT-008" @default.
- NCIT_C148531 NCIT_P208 "CL551138" @default.
- NCIT_C148531 NCIT_P322 "GDC" @default.
- NCIT_C148531 NCIT_P329 "434427" @default.
- NCIT_C148531 NCIT_P330 "434427" @default.
- NCIT_C148531 NCIT_P375 "Paclitaxel Polymeric Micelle Formulation NANT-008" @default.
- NCIT_C148531 NCIT_P399 "434427" @default.
- NCIT_C148531 NCIT_R124 NCIT_C17828 @default.
- NCIT_C148531 NCIT_R124 NCIT_C20480 @default.
- NCIT_C148531 NCIT_R124 NCIT_C40795 @default.
- NCIT_C148531 NCIT_R124 NCIT_C40798 @default.
- NCIT_C148531 normalizedInformationContent "100" @default.
- NCIT_C148531 referenceCount "1" @default.
- NCIT_C148531 hasExactSynonym "Cynviloq" @default.
- NCIT_C148531 hasExactSynonym "Genexol-PM" @default.
- NCIT_C148531 hasExactSynonym "IG-001" @default.
- NCIT_C148531 hasExactSynonym "Micellar Nanoparticle-encapsulated NANT-008" @default.
- NCIT_C148531 hasExactSynonym "NANT 008" @default.
- NCIT_C148531 hasExactSynonym "NANT-008" @default.
- NCIT_C148531 hasExactSynonym "NANT008" @default.
- NCIT_C148531 hasExactSynonym "Nant-paclitaxel" @default.
- NCIT_C148531 hasExactSynonym "Paclitaxel Polymeric Micelle Formulation NANT-008" @default.
- NCIT_C148531 hasExactSynonym "Paclitaxel-loaded Micellar Diblock Copolymer NANT-008" @default.
- NCIT_C148531 hasExactSynonym "Paclitaxel-loaded Polymeric Micelle NANT-008" @default.
- NCIT_C148531 inSubset NCIT_C128784 @default.
- NCIT_C148531 inSubset NCIT_C157711 @default.
- NCIT_C148531 inSubset NCIT_C157712 @default.
- NCIT_C148531 inSubset NCIT_C176424 @default.
- NCIT_C148531 inSubset NCIT_C177537 @default.
- NCIT_C148531 type Class @default.
- NCIT_C148531 isDefinedBy ncit.owl @default.
- NCIT_C148531 label "Paclitaxel Polymeric Micelle Formulation NANT-008" @default.
- NCIT_C148531 subClassOf NCIT_C148531 @default.
- NCIT_C148531 subClassOf NCIT_C186664 @default.
- NCIT_C148531 subClassOf NCIT_C1908 @default.
- NCIT_C148531 subClassOf NCIT_C1909 @default.
- NCIT_C148531 subClassOf NCIT_C25974 @default.
- NCIT_C148531 subClassOf NCIT_C273 @default.
- NCIT_C148531 subClassOf NCIT_C274 @default.
- NCIT_C148531 subClassOf NCIT_C61078 @default.
- NCIT_C148531 subClassOf NCIT_C67437 @default.