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- NCIT_C148532 IAO_0000115 "An orally bioavailable selective inhibitor of the delta isoform of phosphatidylinositide 3-kinase (phosphoinositide 3'-kinase delta; PI3Kd; PI3K-d), with potential antineoplastic activity. Upon oral administration, amdizalisib selectively binds to and inhibits PI3Kd, and prevents the activation of the PI3Kd/AKT signaling pathway, and B-cell activation. This both decreases proliferation and induces cell death in PI3Kd-overexpressing tumor cells. PI3Kd plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation of hematologic cancer cells. The targeted inhibition of PI3Kd is designed to preserve PI3K signaling in normal, non-neoplastic cells and thereby to minimize serious side effects. PI3Kd, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival." @default.
- NCIT_C148532 NCIT_A32 NCIT_C1909 @default.
- NCIT_C148532 NCIT_A7 NCIT_C113631 @default.
- NCIT_C148532 NCIT_NHC0 "C148532" @default.
- NCIT_C148532 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148532 NCIT_P107 "Amdizalisib" @default.
- NCIT_C148532 NCIT_P108 "Amdizalisib" @default.
- NCIT_C148532 NCIT_P208 "CL551137" @default.
- NCIT_C148532 NCIT_P210 "1894229-05-0" @default.
- NCIT_C148532 NCIT_P319 "F3YMY7783P" @default.
- NCIT_C148532 NCIT_P322 "CTRP" @default.
- NCIT_C148532 NCIT_P322 "FDA" @default.
- NCIT_C148532 NCIT_P322 "GDC" @default.
- NCIT_C148532 NCIT_P329 "792706" @default.
- NCIT_C148532 NCIT_P330 "792706" @default.
- NCIT_C148532 NCIT_P375 "PI3K-delta Inhibitor HMPL 689" @default.
- NCIT_C148532 NCIT_P399 "792706" @default.
- NCIT_C148532 normalizedInformationContent "100" @default.
- NCIT_C148532 referenceCount "1" @default.
- NCIT_C148532 hasExactSynonym "AMDIZALISIB" @default.
- NCIT_C148532 hasExactSynonym "Amdizalisib" @default.
- NCIT_C148532 hasExactSynonym "HMPL 689" @default.
- NCIT_C148532 hasExactSynonym "HMPL-689" @default.
- NCIT_C148532 hasExactSynonym "HMPL689" @default.
- NCIT_C148532 hasExactSynonym "PI3K-d Inhibitor HMPL 689" @default.
- NCIT_C148532 hasExactSynonym "PI3K-delta Inhibitor HMPL 689" @default.
- NCIT_C148532 inSubset NCIT_C116977 @default.
- NCIT_C148532 inSubset NCIT_C116978 @default.
- NCIT_C148532 inSubset NCIT_C128784 @default.
- NCIT_C148532 inSubset NCIT_C157711 @default.
- NCIT_C148532 inSubset NCIT_C157712 @default.
- NCIT_C148532 inSubset NCIT_C176424 @default.
- NCIT_C148532 inSubset NCIT_C177537 @default.
- NCIT_C148532 inSubset NCIT_C63923 @default.
- NCIT_C148532 type Class @default.
- NCIT_C148532 isDefinedBy ncit.owl @default.
- NCIT_C148532 label "Amdizalisib" @default.
- NCIT_C148532 subClassOf NCIT_C129824 @default.
- NCIT_C148532 subClassOf NCIT_C129825 @default.
- NCIT_C148532 subClassOf NCIT_C1404 @default.
- NCIT_C148532 subClassOf NCIT_C148532 @default.
- NCIT_C148532 subClassOf NCIT_C163758 @default.
- NCIT_C148532 subClassOf NCIT_C1742 @default.
- NCIT_C148532 subClassOf NCIT_C1908 @default.
- NCIT_C148532 subClassOf NCIT_C1909 @default.
- NCIT_C148532 subClassOf NCIT_C2152 @default.
- NCIT_C148532 subClassOf NCIT_C2189 @default.
- NCIT_C148532 subClassOf NCIT_C274 @default.
- NCIT_C148532 subClassOf NCIT_C471 @default.