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- NCIT_C148539 IAO_0000115 "A vaccine consisting of a recombinant, attenuated, replication-incompetent form of the Semliki Forest Virus (SFV) vector encoding the viral oncoproteins E6 and E7 derived from the human papillomavirus (HPV), with potential immunomodulating and antineoplastic activities. Upon intramuscular administration, HPV E6/E7-encoding SFV vaccine Vvax001 induces expression of the E6/E7 proteins and stimulates both the innate and the adaptive immune system, resulting in a potent cytotoxic T-lymphocyte (CTL) response against and lysis of tumor cells expressing HPV E6 and E7. Oncoproteins E6 and E7 play a key role in the development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma." @default.
- NCIT_C148539 NCIT_NHC0 "C148539" @default.
- NCIT_C148539 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148539 NCIT_P108 "HPV E6/E7-encoding Semliki Forest Virus Vaccine Vvax001" @default.
- NCIT_C148539 NCIT_P208 "CL551130" @default.
- NCIT_C148539 NCIT_P329 "792714" @default.
- NCIT_C148539 NCIT_P330 "792714" @default.
- NCIT_C148539 NCIT_P399 "792714" @default.
- NCIT_C148539 normalizedInformationContent "100" @default.
- NCIT_C148539 referenceCount "1" @default.
- NCIT_C148539 hasExactSynonym "HPV E6/7 Semliki Forest Virus Based Cancer Vaccine" @default.
- NCIT_C148539 hasExactSynonym "HPV E6/E7-encoding Semliki Forest Virus Vaccine Vvax001" @default.
- NCIT_C148539 hasExactSynonym "SFVeE6,7" @default.
- NCIT_C148539 hasExactSynonym "Vvax-001" @default.
- NCIT_C148539 hasExactSynonym "Vvax001 Therapeutic Cancer Vaccine" @default.
- NCIT_C148539 hasExactSynonym "Vvax001" @default.
- NCIT_C148539 hasExactSynonym "rSFVeE6,7" @default.
- NCIT_C148539 inSubset NCIT_C176424 @default.
- NCIT_C148539 type Class @default.
- NCIT_C148539 isDefinedBy ncit.owl @default.
- NCIT_C148539 label "HPV E6/E7-encoding Semliki Forest Virus Vaccine Vvax001" @default.
- NCIT_C148539 subClassOf NCIT_C129820 @default.
- NCIT_C148539 subClassOf NCIT_C148539 @default.
- NCIT_C148539 subClassOf NCIT_C1663 @default.
- NCIT_C148539 subClassOf NCIT_C1908 @default.
- NCIT_C148539 subClassOf NCIT_C1909 @default.
- NCIT_C148539 subClassOf NCIT_C1951 @default.
- NCIT_C148539 subClassOf NCIT_C274 @default.
- NCIT_C148539 subClassOf NCIT_C307 @default.
- NCIT_C148539 subClassOf NCIT_C308 @default.
- NCIT_C148539 subClassOf NCIT_C923 @default.
- NCIT_C148539 subClassOf NCIT_C96404 @default.