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- NCIT_C148637 IAO_0000115 "An inhibitor of the activated form of thrombin-activatable fibrinolysis inhibitor (TAFIa; carboxypeptidase B2; CPB2), with potential fibrinolytic activity. Upon DS-1040 infusion, this agent binds to and inhibits TAFIa. This abrogates TAFIa-mediated inhibition of fibrinolysis. This induces fibrinolysis, degrades fibrin clots and prevents thrombus formation. TAFIa, a carboxypeptidase that is activated by thrombin, cleaves C-terminal amino acid residues from fibrin, which prevents binding and activation of plasminogen and inhibits plasmin-mediated fibrinolysis." @default.
- NCIT_C148637 NCIT_A7 NCIT_C178158 @default.
- NCIT_C148637 NCIT_NHC0 "C148637" @default.
- NCIT_C148637 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C148637 NCIT_P107 "TAFIa Inhibitor DS-1040b" @default.
- NCIT_C148637 NCIT_P108 "TAFIa Inhibitor DS-1040b" @default.
- NCIT_C148637 NCIT_P208 "CL551154" @default.
- NCIT_C148637 NCIT_P322 "CTRP" @default.
- NCIT_C148637 normalizedInformationContent "100" @default.
- NCIT_C148637 referenceCount "1" @default.
- NCIT_C148637 hasExactSynonym "(2S)-5-amino-2-[[1-(4-methylcyclohexyl)imidazol-4-yl]methyl]pentanoic Acid" @default.
- NCIT_C148637 hasExactSynonym "CPB2 Inhibitor DS-1040b" @default.
- NCIT_C148637 hasExactSynonym "Carboxypeptidase B2 Inhibitor DS-1040b" @default.
- NCIT_C148637 hasExactSynonym "Carboxypeptidase U Inhibitor DS-1040b" @default.
- NCIT_C148637 hasExactSynonym "DS 1040" @default.
- NCIT_C148637 hasExactSynonym "DS-1040" @default.
- NCIT_C148637 hasExactSynonym "DS-1040b" @default.
- NCIT_C148637 hasExactSynonym "DS1040" @default.
- NCIT_C148637 hasExactSynonym "Inhibitor of Activated Thrombin Activatable Fibrinolysis Inhibitor DS-1040b" @default.
- NCIT_C148637 hasExactSynonym "TAFIa Inhibitor DS-1040b" @default.
- NCIT_C148637 inSubset NCIT_C116977 @default.
- NCIT_C148637 inSubset NCIT_C116978 @default.
- NCIT_C148637 type Class @default.
- NCIT_C148637 isDefinedBy ncit.owl @default.
- NCIT_C148637 label "TAFIa Inhibitor DS-1040b" @default.
- NCIT_C148637 subClassOf NCIT_C148637 @default.
- NCIT_C148637 subClassOf NCIT_C1908 @default.
- NCIT_C148637 subClassOf NCIT_C1909 @default.
- NCIT_C148637 subClassOf NCIT_C263 @default.
- NCIT_C148637 subClassOf NCIT_C78275 @default.