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- NCIT_C150024 IAO_0000115 "A semi-synthetic, broad-spectrum, fifth-generation cephalosporin antibiotic with bactericidal activity against certain Gram-negative and Gram-positive bacteria. Upon administration, ceftolozane binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. This interferes with the final transpeptidation step required to form peptidoglycan chain cross-links, which are a key component of and provide strength and rigidity to the bacterial cell wall. This inhibits bacterial cell wall synthesis and reduces cell wall stability, which weakens the bacterial cell wall and causes bacterial cell lysis." @default.
- NCIT_C150024 NCIT_NHC0 "C150024" @default.
- NCIT_C150024 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150024 NCIT_P107 "Ceftolozane" @default.
- NCIT_C150024 NCIT_P108 "Ceftolozane" @default.
- NCIT_C150024 NCIT_P208 "CL551786" @default.
- NCIT_C150024 NCIT_P210 "689293-68-3" @default.
- NCIT_C150024 NCIT_P319 "37A4IES95Q" @default.
- NCIT_C150024 NCIT_P322 "CTRP" @default.
- NCIT_C150024 NCIT_P322 "FDA" @default.
- NCIT_C150024 normalizedInformationContent "100" @default.
- NCIT_C150024 referenceCount "1" @default.
- NCIT_C150024 hasExactSynonym "(6R,7R)-3-((5-Amino-4-(((2-aminoethyl)carbamoyl)amino)-1-methyl-1H-pyrazol-2-ium-2- yl)methyl)-7-(((2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-((1-carboxy-1- methylethoxy)imino)acetyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2- Carboxylate" @default.
- NCIT_C150024 hasExactSynonym "5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 3-((4-((((2- Aminoethyl)amino)carbonyl)amino)-2,3-dihydro-3-imino-2-methyl-1H-pyrazol-1- yl)methyl)-7-(((2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-((1-carboxy-1- methylethoxy)imino)acetyl)amino)-8-oxo-, (6R,7R)-" @default.
- NCIT_C150024 hasExactSynonym "CEFTOLOZANE" @default.
- NCIT_C150024 hasExactSynonym "CXA-101" @default.
- NCIT_C150024 hasExactSynonym "Ceftolozane" @default.
- NCIT_C150024 inSubset NCIT_C116977 @default.
- NCIT_C150024 inSubset NCIT_C116978 @default.
- NCIT_C150024 inSubset NCIT_C63923 @default.
- NCIT_C150024 type Class @default.
- NCIT_C150024 isDefinedBy ncit.owl @default.
- NCIT_C150024 label "Ceftolozane" @default.
- NCIT_C150024 subClassOf NCIT_C150024 @default.
- NCIT_C150024 subClassOf NCIT_C1908 @default.
- NCIT_C150024 subClassOf NCIT_C1909 @default.
- NCIT_C150024 subClassOf NCIT_C254 @default.
- NCIT_C150024 subClassOf NCIT_C258 @default.
- NCIT_C150024 subClassOf NCIT_C260 @default.
- NCIT_C150024 subClassOf NCIT_C357 @default.