Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C150127> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- NCIT_C150127 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of a fully human monoclonal antibody against the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA, TNFRSF17) that is site-specifically conjugated, via a protease-cleavable linker, to a cytotoxic, DNA minor groove crosslinking agent and pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity. Upon administration of anti-BCMA/PBD ADC MEDI2228, the antibody moiety targets the cell surface antigen BCMA expressed on certain cancer cells. Upon antibody/antigen binding, internalization and lysosome-mediated cleavage, the cytotoxic PBD moiety is released. In turn, the imine groups of the PBD moiety bind to the N2 positions of guanines on opposite strands of DNA. This induces DNA strand breaks, inhibits DNA replication, leads to G2/M cell cycle arrest, induces cell death, and inhibits the proliferation of BCMA-overexpressing tumor cells. BCMA, a receptor for a proliferation-inducing ligand (APRIL; tumor necrosis factor ligand superfamily member 13; TNFSF13), and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma survival; it is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells." @default.
- NCIT_C150127 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150127 NCIT_A7 NCIT_C97848 @default.
- NCIT_C150127 NCIT_NHC0 "C150127" @default.
- NCIT_C150127 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150127 NCIT_P107 "Anti-BCMA/PBD ADC MEDI2228" @default.
- NCIT_C150127 NCIT_P108 "Anti-BCMA/PBD ADC MEDI2228" @default.
- NCIT_C150127 NCIT_P208 "CL551921" @default.
- NCIT_C150127 NCIT_P319 "YQ4C0NDW44" @default.
- NCIT_C150127 NCIT_P322 "CTRP" @default.
- NCIT_C150127 NCIT_P322 "FDA" @default.
- NCIT_C150127 NCIT_P322 "GDC" @default.
- NCIT_C150127 NCIT_P329 "795378" @default.
- NCIT_C150127 NCIT_P330 "795378" @default.
- NCIT_C150127 NCIT_P375 "Anti-BCMA/PBD ADC MEDI2228" @default.
- NCIT_C150127 NCIT_P399 "795378" @default.
- NCIT_C150127 normalizedInformationContent "100" @default.
- NCIT_C150127 referenceCount "1" @default.
- NCIT_C150127 hasExactSynonym "ADC MEDI2228" @default.
- NCIT_C150127 hasExactSynonym "Anti-BCMA ADC MEDI2228" @default.
- NCIT_C150127 hasExactSynonym "Anti-BCMA/PBD ADC MEDI2228" @default.
- NCIT_C150127 hasExactSynonym "Anti-BCMA/PBD MEDI2228" @default.
- NCIT_C150127 hasExactSynonym "Antibody-drug Conjugate MEDI2228" @default.
- NCIT_C150127 hasExactSynonym "MEDI 2228" @default.
- NCIT_C150127 hasExactSynonym "MEDI-2228" @default.
- NCIT_C150127 hasExactSynonym "MEDI2228" @default.
- NCIT_C150127 inSubset NCIT_C116977 @default.
- NCIT_C150127 inSubset NCIT_C116978 @default.
- NCIT_C150127 inSubset NCIT_C128784 @default.
- NCIT_C150127 inSubset NCIT_C157711 @default.
- NCIT_C150127 inSubset NCIT_C157712 @default.
- NCIT_C150127 inSubset NCIT_C176424 @default.
- NCIT_C150127 inSubset NCIT_C177537 @default.
- NCIT_C150127 inSubset NCIT_C63923 @default.
- NCIT_C150127 type Class @default.
- NCIT_C150127 isDefinedBy ncit.owl @default.
- NCIT_C150127 label "Anti-BCMA/PBD ADC MEDI2228" @default.
- NCIT_C150127 subClassOf NCIT_C129821 @default.
- NCIT_C150127 subClassOf NCIT_C129823 @default.
- NCIT_C150127 subClassOf NCIT_C150127 @default.
- NCIT_C150127 subClassOf NCIT_C1512 @default.
- NCIT_C150127 subClassOf NCIT_C163758 @default.
- NCIT_C150127 subClassOf NCIT_C181108 @default.
- NCIT_C150127 subClassOf NCIT_C181111 @default.
- NCIT_C150127 subClassOf NCIT_C1908 @default.
- NCIT_C150127 subClassOf NCIT_C1909 @default.
- NCIT_C150127 subClassOf NCIT_C274 @default.
- NCIT_C150127 subClassOf NCIT_C307 @default.
- NCIT_C150127 subClassOf NCIT_C308 @default.