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- NCIT_C150216 IAO_0000115 "An orally bioavailable inhibitor of apurinic/apyrimidinic endonuclease 1/reduction-oxidation (redox) effector factor-1 (APE1/Ref-1; APEX1), with potential anti-angiogenic and antineoplastic activities. Upon administration, the APE1/Ref-1 Inhibitor APX3330 selectively targets and binds to APE1/Ref-1. This inhibits the redox-dependent signaling activity of APE1/Ref-1, by preventing the reduction and activation of numerous APE1/Ref-1-dependent oncogenic transcription factors (TFs), such as nuclear factor kappa B (NF-kB), AP-1, STAT3, p53, NRF2 and HIF-1alpha, that are involved in signaling, cell proliferation, tumor progression and survival of cancer cells. Therefore, this agent inhibits the activation of multiple TF-mediated signaling pathways and inhibits tumor cell proliferation and survival. APE1/Ref-1, a multifunctional protein overexpressed in many cancer cell types, plays a key role as a redox regulator of transcription factor activation and in base excision repair upon DNA damage. It drives cancer cell proliferation, migration, drug resistance, angiogenesis and inflammation and its expression level correlates with increased tumor aggressiveness and decreased patient survival. APX3330 specifically blocks the redox activity of APE1/Ref-1 and does not affect its ability to act as a DNA repair endonuclease." @default.
- NCIT_C150216 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150216 NCIT_A7 NCIT_C21415 @default.
- NCIT_C150216 NCIT_NHC0 "C150216" @default.
- NCIT_C150216 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C150216 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150216 NCIT_P107 "APE1/Ref-1 Redox Inhibitor APX3330" @default.
- NCIT_C150216 NCIT_P108 "APE1/Ref-1 Redox Inhibitor APX3330" @default.
- NCIT_C150216 NCIT_P208 "CL551955" @default.
- NCIT_C150216 NCIT_P210 "136164-66-4" @default.
- NCIT_C150216 NCIT_P319 "11267UI968" @default.
- NCIT_C150216 NCIT_P322 "CTRP" @default.
- NCIT_C150216 NCIT_P322 "FDA" @default.
- NCIT_C150216 NCIT_P322 "GDC" @default.
- NCIT_C150216 NCIT_P329 "794415" @default.
- NCIT_C150216 NCIT_P330 "794415" @default.
- NCIT_C150216 NCIT_P375 "APE1/Ref-1 Redox Inhibitor APX3330" @default.
- NCIT_C150216 NCIT_P399 "794415" @default.
- NCIT_C150216 normalizedInformationContent "100" @default.
- NCIT_C150216 referenceCount "1" @default.
- NCIT_C150216 hasExactSynonym "APE1/Ref-1 Inhibitor APX3330" @default.
- NCIT_C150216 hasExactSynonym "APE1/Ref-1 Redox Inhibitor APX3330" @default.
- NCIT_C150216 hasExactSynonym "APX 3330" @default.
- NCIT_C150216 hasExactSynonym "APX-3330" @default.
- NCIT_C150216 hasExactSynonym "APX3330" @default.
- NCIT_C150216 hasExactSynonym "E 3330" @default.
- NCIT_C150216 hasExactSynonym "E3330" @default.
- NCIT_C150216 hasExactSynonym "[(2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic Acid" @default.
- NCIT_C150216 inSubset NCIT_C116977 @default.
- NCIT_C150216 inSubset NCIT_C116978 @default.
- NCIT_C150216 inSubset NCIT_C128784 @default.
- NCIT_C150216 inSubset NCIT_C157711 @default.
- NCIT_C150216 inSubset NCIT_C157712 @default.
- NCIT_C150216 inSubset NCIT_C176424 @default.
- NCIT_C150216 inSubset NCIT_C177537 @default.
- NCIT_C150216 inSubset NCIT_C63923 @default.
- NCIT_C150216 type Class @default.
- NCIT_C150216 isDefinedBy ncit.owl @default.
- NCIT_C150216 label "APE1/Ref-1 Redox Inhibitor APX3330" @default.
- NCIT_C150216 subClassOf NCIT_C129824 @default.
- NCIT_C150216 subClassOf NCIT_C150216 @default.
- NCIT_C150216 subClassOf NCIT_C1742 @default.
- NCIT_C150216 subClassOf NCIT_C1908 @default.
- NCIT_C150216 subClassOf NCIT_C1909 @default.
- NCIT_C150216 subClassOf NCIT_C2189 @default.
- NCIT_C150216 subClassOf NCIT_C274 @default.