Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C150248> ?p ?o ?g. }
Showing items 1 to 46 of
46
with 100 items per page.
- NCIT_C150248 IAO_0000115 "An orally bioavailable inhibitor of the extracellular signal-regulated kinases 1 (ERK1) and 2 (ERK2), with potential antineoplastic activity. Upon oral administration, ERAS-007 specifically binds to and inhibits the serine/threonine-protein kinase activities of both ERK1 and ERK2, thereby preventing the phosphorylation of ERK1/2 substrates and the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent proliferation and survival of tumor cells. The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK pathway, is hyperactivated in a variety of tumor cell types due to mutations in upstream targets. It plays a key role in the proliferation, differentiation and survival of tumor cells." @default.
- NCIT_C150248 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150248 NCIT_A7 NCIT_C17408 @default.
- NCIT_C150248 NCIT_A7 NCIT_C17589 @default.
- NCIT_C150248 NCIT_NHC0 "C150248" @default.
- NCIT_C150248 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150248 NCIT_P107 "ERK1/2 Inhibitor ERAS-007" @default.
- NCIT_C150248 NCIT_P108 "ERK1/2 Inhibitor ERAS-007" @default.
- NCIT_C150248 NCIT_P208 "CL552048" @default.
- NCIT_C150248 NCIT_P322 "CTRP" @default.
- NCIT_C150248 NCIT_P322 "GDC" @default.
- NCIT_C150248 NCIT_P375 "ERK1/2 Inhibitor ASN007" @default.
- NCIT_C150248 NCIT_P399 "805553" @default.
- NCIT_C150248 normalizedInformationContent "100" @default.
- NCIT_C150248 referenceCount "1" @default.
- NCIT_C150248 hasExactSynonym "ASN 007" @default.
- NCIT_C150248 hasExactSynonym "ASN-007" @default.
- NCIT_C150248 hasExactSynonym "ASN007" @default.
- NCIT_C150248 hasExactSynonym "ERAS 007" @default.
- NCIT_C150248 hasExactSynonym "ERAS-007" @default.
- NCIT_C150248 hasExactSynonym "ERAS007" @default.
- NCIT_C150248 hasExactSynonym "ERK Inhibitor ASN007" @default.
- NCIT_C150248 hasExactSynonym "ERK Inhibitor ERAS-007" @default.
- NCIT_C150248 hasExactSynonym "ERK1/2 Inhibitor ASN007" @default.
- NCIT_C150248 hasExactSynonym "ERK1/2 Inhibitor ERAS-007" @default.
- NCIT_C150248 inSubset NCIT_C116977 @default.
- NCIT_C150248 inSubset NCIT_C116978 @default.
- NCIT_C150248 inSubset NCIT_C128784 @default.
- NCIT_C150248 inSubset NCIT_C157711 @default.
- NCIT_C150248 inSubset NCIT_C157712 @default.
- NCIT_C150248 inSubset NCIT_C176424 @default.
- NCIT_C150248 inSubset NCIT_C177537 @default.
- NCIT_C150248 type Class @default.
- NCIT_C150248 isDefinedBy ncit.owl @default.
- NCIT_C150248 label "ERK1/2 Inhibitor ERAS-007" @default.
- NCIT_C150248 subClassOf NCIT_C129824 @default.
- NCIT_C150248 subClassOf NCIT_C129825 @default.
- NCIT_C150248 subClassOf NCIT_C1404 @default.
- NCIT_C150248 subClassOf NCIT_C150248 @default.
- NCIT_C150248 subClassOf NCIT_C174048 @default.
- NCIT_C150248 subClassOf NCIT_C1908 @default.
- NCIT_C150248 subClassOf NCIT_C1909 @default.
- NCIT_C150248 subClassOf NCIT_C2189 @default.
- NCIT_C150248 subClassOf NCIT_C274 @default.
- NCIT_C150248 subClassOf NCIT_C471 @default.
- NCIT_C150248 subClassOf NCIT_C61074 @default.