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- NCIT_C150376 IAO_0000115 "An orally bioavailable antagonist of the prostaglandin E2 receptor subtype 4 (PTGER4; EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration, the EP4 antagonist ONO-4578 selectively targets and binds to EP4, inhibiting the binding of the immunosuppressive prostaglandin E2 (PGE2) to EP4. This prevents the activation of EP4 and inhibits PGE2-EP4-mediated signaling, thereby inhibiting proliferation of tumor cells in which the PGE2-EP4 signaling pathway is over-activated. In addition, EP4 inhibition prevents the activity of tumor-associated myeloid cells (TAMCs) in the tumor microenvironment (TME) by inhibiting interleukin-23 (IL-23) production and the IL-23-mediated expansion of Th17 cells. EP4, a prostanoid receptor, is a G protein-coupled receptor that is expressed in certain types of cancers; it promotes tumor cell proliferation and invasion." @default.
- NCIT_C150376 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150376 NCIT_A7 NCIT_C128194 @default.
- NCIT_C150376 NCIT_NHC0 "C150376" @default.
- NCIT_C150376 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C150376 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C150376 NCIT_P107 "EP4 Antagonist ONO-4578" @default.
- NCIT_C150376 NCIT_P108 "EP4 Antagonist ONO-4578" @default.
- NCIT_C150376 NCIT_P208 "CL552175" @default.
- NCIT_C150376 NCIT_P322 "CTRP" @default.
- NCIT_C150376 NCIT_P322 "GDC" @default.
- NCIT_C150376 NCIT_P329 "792745" @default.
- NCIT_C150376 NCIT_P330 "792745" @default.
- NCIT_C150376 NCIT_P375 "EP4 Antagonist ONO-4578" @default.
- NCIT_C150376 NCIT_P399 "792745" @default.
- NCIT_C150376 normalizedInformationContent "100" @default.
- NCIT_C150376 referenceCount "1" @default.
- NCIT_C150376 hasExactSynonym "BMS-986310" @default.
- NCIT_C150376 hasExactSynonym "EP4 Antagonist ONO-4578" @default.
- NCIT_C150376 hasExactSynonym "ONO 4578" @default.
- NCIT_C150376 hasExactSynonym "ONO-4578" @default.
- NCIT_C150376 hasExactSynonym "ONO4578" @default.
- NCIT_C150376 hasExactSynonym "PGE2 Receptor Antagonist ONO-4578" @default.
- NCIT_C150376 hasExactSynonym "Prostaglandin E2 Receptor Antagonist ONO-4578" @default.
- NCIT_C150376 hasExactSynonym "Selective PGE2 Receptor 4 Antagonist ONO-4578" @default.
- NCIT_C150376 inSubset NCIT_C116977 @default.
- NCIT_C150376 inSubset NCIT_C116978 @default.
- NCIT_C150376 inSubset NCIT_C128784 @default.
- NCIT_C150376 inSubset NCIT_C157711 @default.
- NCIT_C150376 inSubset NCIT_C157712 @default.
- NCIT_C150376 inSubset NCIT_C176424 @default.
- NCIT_C150376 inSubset NCIT_C177537 @default.
- NCIT_C150376 type Class @default.
- NCIT_C150376 isDefinedBy ncit.owl @default.
- NCIT_C150376 label "EP4 Antagonist ONO-4578" @default.
- NCIT_C150376 subClassOf NCIT_C129820 @default.
- NCIT_C150376 subClassOf NCIT_C150376 @default.
- NCIT_C150376 subClassOf NCIT_C1908 @default.
- NCIT_C150376 subClassOf NCIT_C1909 @default.
- NCIT_C150376 subClassOf NCIT_C192825 @default.
- NCIT_C150376 subClassOf NCIT_C274 @default.
- NCIT_C150376 subClassOf NCIT_C308 @default.