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- NCIT_C150382 IAO_0000115 "A preparation of autologous T-lymphocytes ex vivo transduced with a lentiviral vector encoding for a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CLDN18.2CAR-transduced T lymphocytes specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C150382 NCIT_NHC0 "C150382" @default.
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- NCIT_C150382 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150382 NCIT_P107 "Autologous Anti-Claudin18.2-transduced T Lymphocytes CT041" @default.
- NCIT_C150382 NCIT_P108 "Autologous Anti-Claudin18.2-transduced T Lymphocytes CT041" @default.
- NCIT_C150382 NCIT_P208 "CL552166" @default.
- NCIT_C150382 NCIT_P322 "CTRP" @default.
- NCIT_C150382 NCIT_P329 "792788" @default.
- NCIT_C150382 NCIT_P330 "792788" @default.
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- NCIT_C150382 normalizedInformationContent "100" @default.
- NCIT_C150382 referenceCount "1" @default.
- NCIT_C150382 hasExactSynonym "Autologous Anti-Claudin18.2 CAR-T Cells" @default.
- NCIT_C150382 hasExactSynonym "Autologous Anti-Claudin18.2-transduced T Lymphocytes CT041" @default.
- NCIT_C150382 hasExactSynonym "Autologous CAR-CLD18 T Cells" @default.
- NCIT_C150382 hasExactSynonym "Autologous CAR-CLD18.2 T Cells" @default.
- NCIT_C150382 hasExactSynonym "CT 041" @default.
- NCIT_C150382 hasExactSynonym "CT-041" @default.
- NCIT_C150382 hasExactSynonym "CT041" @default.
- NCIT_C150382 hasExactSynonym "Claudin18.2-redirected Autologous Cells" @default.
- NCIT_C150382 inSubset NCIT_C116977 @default.
- NCIT_C150382 inSubset NCIT_C116978 @default.
- NCIT_C150382 inSubset NCIT_C176424 @default.
- NCIT_C150382 type Class @default.
- NCIT_C150382 isDefinedBy ncit.owl @default.
- NCIT_C150382 label "Autologous Anti-Claudin18.2-transduced T Lymphocytes CT041" @default.
- NCIT_C150382 subClassOf NCIT_C129820 @default.
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