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- NCIT_C150384 IAO_0000115 "Radiopaque drug-eluting beads (DEBs) that are loaded with vandetanib, a dual inhibitor of both vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR), with potential antineoplastic, anti-angiogenic and imaging activities. Upon intra-arterial hepatic artery administration of vandetanib (VTB)-eluting Radiopaque beads (VERBs) BTG-002814, the DEBs occlude the tumor blood vessels and deprive tumor cells of oxygen and nutrients, thereby causing hepatic arterial embolization and direct tumor cell death. The VERBs release vandetanib from the beads in a sustained manner. Vandetanib selectively inhibits the tyrosine kinase activity of both VEGFR and EGFR, thereby blocking both VEGF/VEGFR- and EGF/EGFR-stimulated signaling and inhibiting cell proliferation, migration and angiogenesis in VEGFR/EGFR-expressing hepatic tumor cells. The DEBs, controlled release microspherical devices, cause low systemic exposure and prevent systemic toxicity of vandetanib. DEBs also deliver high concentrations of vandetanib in the tumor for a controlled and extended period of time. Use of radiopaque DEBs allows for visualization of both the bead location and the degree of embolization upon imaging." @default.
- NCIT_C150384 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150384 NCIT_NHC0 "C150384" @default.
- NCIT_C150384 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150384 NCIT_P108 "Vandetanib-eluting Radiopaque Bead BTG-002814" @default.
- NCIT_C150384 NCIT_P208 "CL552167" @default.
- NCIT_C150384 NCIT_P322 "GDC" @default.
- NCIT_C150384 NCIT_P329 "792793" @default.
- NCIT_C150384 NCIT_P330 "792793" @default.
- NCIT_C150384 NCIT_P375 "Vandetanib-eluting Radiopaque Bead BTG-002814" @default.
- NCIT_C150384 NCIT_P399 "792793" @default.
- NCIT_C150384 normalizedInformationContent "100" @default.
- NCIT_C150384 referenceCount "1" @default.
- NCIT_C150384 hasExactSynonym "BTG-002814" @default.
- NCIT_C150384 hasExactSynonym "VERB BTG-002814" @default.
- NCIT_C150384 hasExactSynonym "VERB" @default.
- NCIT_C150384 hasExactSynonym "VTB-loaded Beads" @default.
- NCIT_C150384 hasExactSynonym "Vandetanib-eluting Radiopaque Bead BTG-002814" @default.
- NCIT_C150384 hasExactSynonym "Vandetanib-eluting Radiopaque Embolic Beads" @default.
- NCIT_C150384 inSubset NCIT_C128784 @default.
- NCIT_C150384 inSubset NCIT_C157711 @default.
- NCIT_C150384 inSubset NCIT_C157712 @default.
- NCIT_C150384 inSubset NCIT_C176424 @default.
- NCIT_C150384 inSubset NCIT_C177537 @default.
- NCIT_C150384 type Class @default.
- NCIT_C150384 isDefinedBy ncit.owl @default.
- NCIT_C150384 label "Vandetanib-eluting Radiopaque Bead BTG-002814" @default.
- NCIT_C150384 subClassOf NCIT_C129824 @default.
- NCIT_C150384 subClassOf NCIT_C129825 @default.
- NCIT_C150384 subClassOf NCIT_C1404 @default.
- NCIT_C150384 subClassOf NCIT_C150384 @default.
- NCIT_C150384 subClassOf NCIT_C163758 @default.
- NCIT_C150384 subClassOf NCIT_C163953 @default.
- NCIT_C150384 subClassOf NCIT_C1742 @default.
- NCIT_C150384 subClassOf NCIT_C1908 @default.
- NCIT_C150384 subClassOf NCIT_C1909 @default.
- NCIT_C150384 subClassOf NCIT_C1967 @default.
- NCIT_C150384 subClassOf NCIT_C2189 @default.
- NCIT_C150384 subClassOf NCIT_C274 @default.
- NCIT_C150384 subClassOf NCIT_C471 @default.
- NCIT_C150384 subClassOf NCIT_C93259 @default.