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- NCIT_C150413 IAO_0000115 "The hydrochloride salt form of CB-839, an orally bioavailable inhibitor of glutaminase, with potential antineoplastic and immunostimulating activities. Upon oral administration, CB-839 selectively and reversibly binds to and inhibits human glutaminase, an enzyme that is essential for the conversion of the amino acid glutamine into glutamate. Blocking glutamine metabolism inhibits proliferation in rapidly growing tumor cells and leads to an induction of cell death. Unlike normal healthy cells, glutamine-dependent tumors heavily rely on the intracellular conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. In addition, CB-839 causes accumulation of glutamine in tumor cells and increases glutamine concentration in the tumor microenvironment (TME) upon cell death. As glutamine is essential for T-cell generation, CB-839 may also enhance T-cell proliferation and activation in the TME, which may lead to further killing of tumor cells." @default.
- NCIT_C150413 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150413 NCIT_A7 NCIT_C128179 @default.
- NCIT_C150413 NCIT_NHC0 "C150413" @default.
- NCIT_C150413 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150413 NCIT_P107 "Telaglenastat Hydrochloride" @default.
- NCIT_C150413 NCIT_P108 "Telaglenastat Hydrochloride" @default.
- NCIT_C150413 NCIT_P208 "CL552142" @default.
- NCIT_C150413 NCIT_P210 "1874231-60-3" @default.
- NCIT_C150413 NCIT_P319 "B33561JJ61" @default.
- NCIT_C150413 NCIT_P322 "CTRP" @default.
- NCIT_C150413 NCIT_P322 "FDA" @default.
- NCIT_C150413 NCIT_P322 "GDC" @default.
- NCIT_C150413 NCIT_P329 "801359" @default.
- NCIT_C150413 NCIT_P330 "801359" @default.
- NCIT_C150413 NCIT_P375 "Glutaminase Inhibitor CB-839 Hydrochloride" @default.
- NCIT_C150413 NCIT_P375 "Telaglenastat Hydrochloride" @default.
- NCIT_C150413 NCIT_P399 "801359" @default.
- NCIT_C150413 normalizedInformationContent "100" @default.
- NCIT_C150413 referenceCount "1" @default.
- NCIT_C150413 hasExactSynonym "2-Pyridineacetamide, N-(5-(4-(6-((2-(3-(trifluoromethoxy)phenyl)acetyl)amino)-3-pyridazinyl)butyl)-1,3,4-thiadiazol-2-yl)-, Hydrochloride (1:1)" @default.
- NCIT_C150413 hasExactSynonym "CB-839 HCl" @default.
- NCIT_C150413 hasExactSynonym "Glutaminase Inhibitor CB-839 Hydrochloride" @default.
- NCIT_C150413 hasExactSynonym "TELAGLENASTAT HYDROCHLORIDE" @default.
- NCIT_C150413 hasExactSynonym "Telaglenastat Hydrochloride" @default.
- NCIT_C150413 inSubset NCIT_C116977 @default.
- NCIT_C150413 inSubset NCIT_C116978 @default.
- NCIT_C150413 inSubset NCIT_C128784 @default.
- NCIT_C150413 inSubset NCIT_C157711 @default.
- NCIT_C150413 inSubset NCIT_C157712 @default.
- NCIT_C150413 inSubset NCIT_C176424 @default.
- NCIT_C150413 inSubset NCIT_C177537 @default.
- NCIT_C150413 inSubset NCIT_C63923 @default.
- NCIT_C150413 type Class @default.
- NCIT_C150413 isDefinedBy ncit.owl @default.
- NCIT_C150413 label "Telaglenastat Hydrochloride" @default.
- NCIT_C150413 subClassOf NCIT_C150413 @default.
- NCIT_C150413 subClassOf NCIT_C1908 @default.
- NCIT_C150413 subClassOf NCIT_C1909 @default.
- NCIT_C150413 subClassOf NCIT_C471 @default.