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- NCIT_C150429 IAO_0000115 "A radioconjugate containing the biphosphonate alendronate conjugated with the bifunctional, macrocyclic chelating agent 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) and labeled with the radioisotope copper Cu 64, with potential use as an imaging agent for microcalcifications in mammary tumors using positron emission tomography (PET). Upon administration of the copper Cu-64 alendronate, the alendronate moiety targets and binds to hydroxyapatite crystals found in malignant tumors. Upon binding and PET imaging, the radioisotope moiety is detected, thereby allowing differentiation between malignant tumors, benign tumors and normal tissue, as the highest uptake of 64Cu-DOTA-alendronate occurs in malignant tumors while the lowest uptake occurs in benign tumors and normal mammary tissue." @default.
- NCIT_C150429 NCIT_NHC0 "C150429" @default.
- NCIT_C150429 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C150429 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C150429 NCIT_P107 "Copper Cu-64-DOTA-alendronate" @default.
- NCIT_C150429 NCIT_P108 "Copper Cu-64-DOTA-alendronate" @default.
- NCIT_C150429 NCIT_P208 "CL552243" @default.
- NCIT_C150429 NCIT_P322 "CTRP" @default.
- NCIT_C150429 NCIT_P329 "793386" @default.
- NCIT_C150429 NCIT_P330 "793386" @default.
- NCIT_C150429 NCIT_P366 "Copper_Cu_64_Trastuzumab" @default.
- NCIT_C150429 NCIT_P399 "793386" @default.
- NCIT_C150429 normalizedInformationContent "100" @default.
- NCIT_C150429 referenceCount "1" @default.
- NCIT_C150429 hasExactSynonym "64Cu-DOTA-alendronate" @default.
- NCIT_C150429 hasExactSynonym "Copper Cu-64-DOTA-alendronate" @default.
- NCIT_C150429 hasExactSynonym "[64Cu]-DOTA-alendronate" @default.
- NCIT_C150429 inSubset NCIT_C116977 @default.
- NCIT_C150429 inSubset NCIT_C116978 @default.
- NCIT_C150429 inSubset NCIT_C176424 @default.
- NCIT_C150429 type Class @default.
- NCIT_C150429 isDefinedBy ncit.owl @default.
- NCIT_C150429 label "Copper Cu-64-DOTA-alendronate" @default.
- NCIT_C150429 subClassOf NCIT_C1446 @default.
- NCIT_C150429 subClassOf NCIT_C150429 @default.
- NCIT_C150429 subClassOf NCIT_C1511 @default.
- NCIT_C150429 subClassOf NCIT_C1512 @default.
- NCIT_C150429 subClassOf NCIT_C1908 @default.
- NCIT_C150429 subClassOf NCIT_C1909 @default.
- NCIT_C150429 subClassOf NCIT_C2124 @default.
- NCIT_C150429 subClassOf NCIT_C307 @default.
- NCIT_C150429 subClassOf NCIT_C308 @default.