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- NCIT_C150463 IAO_0000115 "A Fc-engineered bispecific antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, vudalimab targets and binds to both PD-1 and CTLA4 expressed on tumor-infiltrating T-lymphocytes (TILs) and inhibits the PD-1- and CTLA4-mediated downregulation of T-cell activation and proliferation. This restores immune function and activates a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Both PD-1 and CTLA4 are selectively expressed on TILs in the tumor microenvironment (TME) and negatively regulate the activation and effector functions of T-cells. They play key roles in the downregulation of the immune system and tumor evasion from host immunity. Dual checkpoint blockade of PD1 and CTLA4 with XmAb20717 may enhance T cell activation and proliferation more than the blockade of either immune checkpoint receptor alone. The engineered Fc domain increases the stability and half-life of the antibody." @default.
- NCIT_C150463 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150463 NCIT_A7 NCIT_C17489 @default.
- NCIT_C150463 NCIT_NHC0 "C150463" @default.
- NCIT_C150463 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150463 NCIT_P107 "Vudalimab" @default.
- NCIT_C150463 NCIT_P108 "Vudalimab" @default.
- NCIT_C150463 NCIT_P208 "CL552206" @default.
- NCIT_C150463 NCIT_P210 "2329669-72-7" @default.
- NCIT_C150463 NCIT_P319 "4I9I5X3Z6N" @default.
- NCIT_C150463 NCIT_P322 "CTRP" @default.
- NCIT_C150463 NCIT_P322 "FDA" @default.
- NCIT_C150463 NCIT_P322 "GDC" @default.
- NCIT_C150463 NCIT_P329 "793410" @default.
- NCIT_C150463 NCIT_P330 "793410" @default.
- NCIT_C150463 NCIT_P375 "Anti-PD1/CTLA4 Bispecific Antibody XmAb20717" @default.
- NCIT_C150463 NCIT_P399 "793410" @default.
- NCIT_C150463 NCIT_R124 NCIT_C17710 @default.
- NCIT_C150463 NCIT_R124 NCIT_C17828 @default.
- NCIT_C150463 NCIT_R124 NCIT_C18219 @default.
- NCIT_C150463 NCIT_R124 NCIT_C19986 @default.
- NCIT_C150463 NCIT_R124 NCIT_C40474 @default.
- NCIT_C150463 normalizedInformationContent "100" @default.
- NCIT_C150463 referenceCount "1" @default.
- NCIT_C150463 hasExactSynonym "Anti-PD-1/Anti-CTLA-4 XmAb20717" @default.
- NCIT_C150463 hasExactSynonym "Anti-PD1/CTLA4 Bispecific Antibody XmAb20717" @default.
- NCIT_C150463 hasExactSynonym "PD-1 x CTLA-4 Bispecific Antibody XmAb20717" @default.
- NCIT_C150463 hasExactSynonym "PD-1 x CTLA-4 Dual Checkpoint Inhibitor XmAb20717" @default.
- NCIT_C150463 hasExactSynonym "VUDALIMAB" @default.
- NCIT_C150463 hasExactSynonym "Vudalimab" @default.
- NCIT_C150463 hasExactSynonym "XmAb 20717" @default.
- NCIT_C150463 hasExactSynonym "XmAb20717" @default.
- NCIT_C150463 inSubset NCIT_C116977 @default.
- NCIT_C150463 inSubset NCIT_C116978 @default.
- NCIT_C150463 inSubset NCIT_C128784 @default.
- NCIT_C150463 inSubset NCIT_C157711 @default.
- NCIT_C150463 inSubset NCIT_C157712 @default.
- NCIT_C150463 inSubset NCIT_C176424 @default.
- NCIT_C150463 inSubset NCIT_C177537 @default.
- NCIT_C150463 inSubset NCIT_C63923 @default.
- NCIT_C150463 type Class @default.
- NCIT_C150463 isDefinedBy ncit.owl @default.
- NCIT_C150463 label "Vudalimab" @default.
- NCIT_C150463 subClassOf NCIT_C128036 @default.
- NCIT_C150463 subClassOf NCIT_C129821 @default.
- NCIT_C150463 subClassOf NCIT_C129822 @default.
- NCIT_C150463 subClassOf NCIT_C141144 @default.
- NCIT_C150463 subClassOf NCIT_C143250 @default.
- NCIT_C150463 subClassOf NCIT_C1454 @default.
- NCIT_C150463 subClassOf NCIT_C150463 @default.
- NCIT_C150463 subClassOf NCIT_C163758 @default.
- NCIT_C150463 subClassOf NCIT_C1908 @default.
- NCIT_C150463 subClassOf NCIT_C1909 @default.
- NCIT_C150463 subClassOf NCIT_C191738 @default.
- NCIT_C150463 subClassOf NCIT_C20401 @default.
- NCIT_C150463 subClassOf NCIT_C274 @default.
- NCIT_C150463 subClassOf NCIT_C28227 @default.
- NCIT_C150463 subClassOf NCIT_C307 @default.
- NCIT_C150463 subClassOf NCIT_C308 @default.