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- NCIT_C150507 IAO_0000115 "A mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins), with potential antineoplastic activity. Upon administration, Smac mimetic BI 891065 targets and binds to the Smac binding groove on IAPs, including the caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting certain caspases." @default.
- NCIT_C150507 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150507 NCIT_NHC0 "C150507" @default.
- NCIT_C150507 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150507 NCIT_P108 "SMAC Mimetic BI 891065" @default.
- NCIT_C150507 NCIT_P208 "CL552291" @default.
- NCIT_C150507 NCIT_P322 "GDC" @default.
- NCIT_C150507 NCIT_P329 "793013" @default.
- NCIT_C150507 NCIT_P330 "793013" @default.
- NCIT_C150507 NCIT_P375 "SMAC Mimetic BI 891065" @default.
- NCIT_C150507 NCIT_P399 "793013" @default.
- NCIT_C150507 normalizedInformationContent "100" @default.
- NCIT_C150507 referenceCount "1" @default.
- NCIT_C150507 hasExactSynonym "BI 891065" @default.
- NCIT_C150507 hasExactSynonym "SMAC Mimetic BI 891065" @default.
- NCIT_C150507 inSubset NCIT_C128784 @default.
- NCIT_C150507 inSubset NCIT_C157711 @default.
- NCIT_C150507 inSubset NCIT_C157712 @default.
- NCIT_C150507 inSubset NCIT_C176424 @default.
- NCIT_C150507 inSubset NCIT_C177537 @default.
- NCIT_C150507 type Class @default.
- NCIT_C150507 isDefinedBy ncit.owl @default.
- NCIT_C150507 label "SMAC Mimetic BI 891065" @default.
- NCIT_C150507 subClassOf NCIT_C129839 @default.
- NCIT_C150507 subClassOf NCIT_C150507 @default.
- NCIT_C150507 subClassOf NCIT_C1908 @default.
- NCIT_C150507 subClassOf NCIT_C1909 @default.
- NCIT_C150507 subClassOf NCIT_C274 @default.