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- NCIT_C150517 IAO_0000115 "A cancer vaccine composed of a genetically engineered, replication-defective oncolytic adenovirus serotype 5 (Ad5) vector, in which the E1, E2b and E3 genes are deleted, that encodes a modified version of the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2/neu; ErbB-2; ERBB2), with potential antineoplastic activity. Upon administration of Ad5 [E1-, E2b-]-HER2/neu ETBX-021, the vector expresses HER2/neu and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells expressing the HER2/neu antigen. This results in the immune-mediated induction of death in and inhibition of proliferation of HER2/neu-expressing tumor cells. HER2/neu, a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in various tumor cell types while expression is restricted and minimal in certain normal healthy cells. It plays a key role in cancer cell proliferation and survival. The gene deletions in Ad5 may circumvent pre-existing anti-adenovirus immunity, allow HER2 gene insertion and expression and induce a strong immune response." @default.
- NCIT_C150517 NCIT_NHC0 "C150517" @default.
- NCIT_C150517 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150517 NCIT_P106 "Virus" @default.
- NCIT_C150517 NCIT_P108 "Ad5 [E1-, E2b-]-HER2/Neu Vaccine ETBX-021" @default.
- NCIT_C150517 NCIT_P208 "CL552279" @default.
- NCIT_C150517 NCIT_P210 "2171509-20-7" @default.
- NCIT_C150517 NCIT_P319 "S4MK9TOL0D" @default.
- NCIT_C150517 NCIT_P322 "FDA" @default.
- NCIT_C150517 NCIT_P329 "793072" @default.
- NCIT_C150517 NCIT_P330 "793072" @default.
- NCIT_C150517 NCIT_P399 "793072" @default.
- NCIT_C150517 normalizedInformationContent "100" @default.
- NCIT_C150517 referenceCount "1" @default.
- NCIT_C150517 hasExactSynonym "Ad5 [E1-, E2b-]-HER2/Neu Vaccine ETBX-021" @default.
- NCIT_C150517 hasExactSynonym "Ad5 [E1-, E2b-]-HER2/neu Vaccine" @default.
- NCIT_C150517 hasExactSynonym "Adenovirus Type 5 E1/E2b-deleted HER2/neu Vaccine ETBX-021" @default.
- NCIT_C150517 hasExactSynonym "ETBX-021" @default.
- NCIT_C150517 inSubset NCIT_C176424 @default.
- NCIT_C150517 inSubset NCIT_C63923 @default.
- NCIT_C150517 type Class @default.
- NCIT_C150517 isDefinedBy ncit.owl @default.
- NCIT_C150517 label "Ad5 [E1-, E2b-]-HER2/Neu Vaccine ETBX-021" @default.
- NCIT_C150517 subClassOf NCIT_C129820 @default.
- NCIT_C150517 subClassOf NCIT_C150517 @default.
- NCIT_C150517 subClassOf NCIT_C1572 @default.
- NCIT_C150517 subClassOf NCIT_C1663 @default.
- NCIT_C150517 subClassOf NCIT_C1908 @default.
- NCIT_C150517 subClassOf NCIT_C1909 @default.
- NCIT_C150517 subClassOf NCIT_C274 @default.
- NCIT_C150517 subClassOf NCIT_C307 @default.
- NCIT_C150517 subClassOf NCIT_C308 @default.
- NCIT_C150517 subClassOf NCIT_C49146 @default.
- NCIT_C150517 subClassOf NCIT_C923 @default.
- NCIT_C150517 subClassOf NCIT_C96404 @default.