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- NCIT_C150558 IAO_0000115 "A fully human immunoglobulin G2 (IgG2) agonistic monoclonal antibody targeting the B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, CDX-1140 targets and binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs) and activates T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages and B-cells, and plays a key role in the activation of the immune system." @default.
- NCIT_C150558 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150558 NCIT_A7 NCIT_C17281 @default.
- NCIT_C150558 NCIT_NHC0 "C150558" @default.
- NCIT_C150558 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C150558 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150558 NCIT_P107 "Anti-CD40 Agonist Monoclonal Antibody CDX-1140" @default.
- NCIT_C150558 NCIT_P108 "Anti-CD40 Agonist Monoclonal Antibody CDX-1140" @default.
- NCIT_C150558 NCIT_P208 "CL552359" @default.
- NCIT_C150558 NCIT_P319 "OWK8BG0FO6" @default.
- NCIT_C150558 NCIT_P322 "CTRP" @default.
- NCIT_C150558 NCIT_P322 "FDA" @default.
- NCIT_C150558 NCIT_P322 "GDC" @default.
- NCIT_C150558 NCIT_P329 "793440" @default.
- NCIT_C150558 NCIT_P330 "793440" @default.
- NCIT_C150558 NCIT_P375 "Anti-CD40 Agonist Monoclonal Antibody CDX-1140" @default.
- NCIT_C150558 NCIT_P399 "793440" @default.
- NCIT_C150558 NCIT_R124 NCIT_C17710 @default.
- NCIT_C150558 NCIT_R124 NCIT_C17828 @default.
- NCIT_C150558 NCIT_R124 NCIT_C18219 @default.
- NCIT_C150558 NCIT_R124 NCIT_C19986 @default.
- NCIT_C150558 NCIT_R124 NCIT_C40474 @default.
- NCIT_C150558 normalizedInformationContent "100" @default.
- NCIT_C150558 referenceCount "1" @default.
- NCIT_C150558 hasExactSynonym "Agonist CD40 Antibody CDX-1140" @default.
- NCIT_C150558 hasExactSynonym "Anti-CD40 Agonist Monoclonal Antibody CDX-1140" @default.
- NCIT_C150558 hasExactSynonym "Anti-CD40 Agonistic Monoclonal Antibody CDX-1140" @default.
- NCIT_C150558 hasExactSynonym "CDX 1140" @default.
- NCIT_C150558 hasExactSynonym "CDX-1140" @default.
- NCIT_C150558 inSubset NCIT_C116977 @default.
- NCIT_C150558 inSubset NCIT_C116978 @default.
- NCIT_C150558 inSubset NCIT_C128784 @default.
- NCIT_C150558 inSubset NCIT_C157711 @default.
- NCIT_C150558 inSubset NCIT_C157712 @default.
- NCIT_C150558 inSubset NCIT_C176424 @default.
- NCIT_C150558 inSubset NCIT_C177537 @default.
- NCIT_C150558 inSubset NCIT_C63923 @default.
- NCIT_C150558 type Class @default.
- NCIT_C150558 isDefinedBy ncit.owl @default.
- NCIT_C150558 label "Anti-CD40 Agonist Monoclonal Antibody CDX-1140" @default.
- NCIT_C150558 subClassOf NCIT_C129820 @default.
- NCIT_C150558 subClassOf NCIT_C133877 @default.
- NCIT_C150558 subClassOf NCIT_C150558 @default.
- NCIT_C150558 subClassOf NCIT_C1908 @default.
- NCIT_C150558 subClassOf NCIT_C1909 @default.
- NCIT_C150558 subClassOf NCIT_C191767 @default.
- NCIT_C150558 subClassOf NCIT_C20401 @default.
- NCIT_C150558 subClassOf NCIT_C274 @default.
- NCIT_C150558 subClassOf NCIT_C307 @default.
- NCIT_C150558 subClassOf NCIT_C308 @default.