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- NCIT_C150671 IAO_0000115 "A preparation of autologous T-lymphocytes that are engineered to express a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv) linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration of the autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells, these cells target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies." @default.
- NCIT_C150671 NCIT_A7 NCIT_C38894 @default.
- NCIT_C150671 NCIT_NHC0 "C150671" @default.
- NCIT_C150671 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150671 NCIT_P107 "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells" @default.
- NCIT_C150671 NCIT_P108 "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells" @default.
- NCIT_C150671 NCIT_P208 "CL552563" @default.
- NCIT_C150671 NCIT_P322 "CTRP" @default.
- NCIT_C150671 NCIT_P329 "793525" @default.
- NCIT_C150671 NCIT_P330 "793525" @default.
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- NCIT_C150671 normalizedInformationContent "100" @default.
- NCIT_C150671 referenceCount "1" @default.
- NCIT_C150671 hasExactSynonym "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells" @default.
- NCIT_C150671 hasExactSynonym "Autologous CD19CAR-CD3zeta-4-1BB-expressing T-lymphocytes" @default.
- NCIT_C150671 hasExactSynonym "Autologous CD3zeta-4-1BB-expressing CART-19 Cells" @default.
- NCIT_C150671 inSubset NCIT_C116977 @default.
- NCIT_C150671 inSubset NCIT_C116978 @default.
- NCIT_C150671 inSubset NCIT_C128784 @default.
- NCIT_C150671 inSubset NCIT_C176424 @default.
- NCIT_C150671 type Class @default.
- NCIT_C150671 isDefinedBy ncit.owl @default.
- NCIT_C150671 label "Autologous Anti-CD19 CAR-CD3zeta-4-1BB-expressing T-cells" @default.
- NCIT_C150671 subClassOf NCIT_C129820 @default.
- NCIT_C150671 subClassOf NCIT_C129821 @default.
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- NCIT_C150671 subClassOf NCIT_C307 @default.
- NCIT_C150671 subClassOf NCIT_C308 @default.