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- NCIT_C150717 IAO_0000115 "A gold nanoparticle (GNP)-based formulation containing panobinostat, a pan histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon intra-tumoral injection of MTX110, panobinostat is released from the formulation and selectively targets, binds to and inhibits histone deacetylase (HDAC), which induces hyperacetylation of core histone proteins. The accumulation of highly acetylated histones leads to chromatin remodeling, an altered pattern of gene expression, inhibition of tumor oncogene transcription and the selective transcription of tumor suppressor genes. This results in the inhibition of tumor cell division and the induction of tumor cell apoptosis. HDAC, upregulated in many tumor cell types, is an enzyme family that deacetylates histone proteins. Panobinostat is water insoluble and does not cross the blood-brain barrier (BBB) when administered orally or intravenously. MTX110 solubilizes panobinostat and can be directly injected into the brain, which bypasses the BBB and delivers high concentrations of panobinostat to the tumor, while minimizing systemic toxicity." @default.
- NCIT_C150717 NCIT_A32 NCIT_C1909 @default.
- NCIT_C150717 NCIT_A7 NCIT_C16682 @default.
- NCIT_C150717 NCIT_NHC0 "C150717" @default.
- NCIT_C150717 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150717 NCIT_P107 "Panobinostat Nanoparticle Formulation MTX110" @default.
- NCIT_C150717 NCIT_P108 "Panobinostat Nanoparticle Formulation MTX110" @default.
- NCIT_C150717 NCIT_P208 "CL552518" @default.
- NCIT_C150717 NCIT_P322 "CTRP" @default.
- NCIT_C150717 NCIT_P322 "GDC" @default.
- NCIT_C150717 NCIT_P329 "793526" @default.
- NCIT_C150717 NCIT_P330 "793526" @default.
- NCIT_C150717 NCIT_P375 "Panobinostat Nanoparticle Formulation MTX110" @default.
- NCIT_C150717 NCIT_P399 "793526" @default.
- NCIT_C150717 normalizedInformationContent "100" @default.
- NCIT_C150717 referenceCount "1" @default.
- NCIT_C150717 hasExactSynonym "MTX 110" @default.
- NCIT_C150717 hasExactSynonym "MTX-110" @default.
- NCIT_C150717 hasExactSynonym "MTX110" @default.
- NCIT_C150717 hasExactSynonym "Panobinostat Nanoparticle Formulation MTX110" @default.
- NCIT_C150717 inSubset NCIT_C116977 @default.
- NCIT_C150717 inSubset NCIT_C116978 @default.
- NCIT_C150717 inSubset NCIT_C128784 @default.
- NCIT_C150717 inSubset NCIT_C157711 @default.
- NCIT_C150717 inSubset NCIT_C157712 @default.
- NCIT_C150717 inSubset NCIT_C176424 @default.
- NCIT_C150717 inSubset NCIT_C177537 @default.
- NCIT_C150717 type Class @default.
- NCIT_C150717 isDefinedBy ncit.owl @default.
- NCIT_C150717 label "Panobinostat Nanoparticle Formulation MTX110" @default.
- NCIT_C150717 subClassOf NCIT_C129824 @default.
- NCIT_C150717 subClassOf NCIT_C129825 @default.
- NCIT_C150717 subClassOf NCIT_C150717 @default.
- NCIT_C150717 subClassOf NCIT_C163758 @default.
- NCIT_C150717 subClassOf NCIT_C1908 @default.
- NCIT_C150717 subClassOf NCIT_C1909 @default.
- NCIT_C150717 subClassOf NCIT_C1946 @default.
- NCIT_C150717 subClassOf NCIT_C2189 @default.
- NCIT_C150717 subClassOf NCIT_C274 @default.
- NCIT_C150717 subClassOf NCIT_C471 @default.