Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C150906> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- NCIT_C150906 IAO_0000115 "A preparation of autologous, genetically modified T-lymphocytes, that have been electroporated ex vivo with sleeping beauty (SB)-derived DNA plasmids, expressing a second-generation chimeric antigen receptor (CAR) composed of a mouse single-chain variable fragment (scFv) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19) that is linked to the co-stimulatory molecules T-cell surface glycoproteins CD8 and CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta) and co-expressed with a chimeric membrane-bound fusion protein comprised of interleukin-15 (IL-15) fused to IL-15 receptor (mbIL15) and a safety/kill switch composed of a truncated form of the human epidermal growth factor receptor (ErbB1t; EGFR) (HER1t), with potential immunostimulating and antineoplastic activities. Upon reintroduction of the autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T cells into the patient, the T-cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. HER1t can promote selective elimination of the CAR-T cells through cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells and use of mbIL15 preserves T stem-cell memory (TSCM) through sustained IL-15 signaling, improves T-cell persistence and potentiates the immune response against tumor cells. The SB system permits electroporation of the CAR, the IL-15 fusion variant and safety switch transgenes into T-cells without the need for viral vectors and accelerates the manufacturing process." @default.
- NCIT_C150906 NCIT_A7 NCIT_C38894 @default.
- NCIT_C150906 NCIT_NHC0 "C150906" @default.
- NCIT_C150906 NCIT_P106 "Cell" @default.
- NCIT_C150906 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C150906 NCIT_P107 "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells" @default.
- NCIT_C150906 NCIT_P108 "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells" @default.
- NCIT_C150906 NCIT_P208 "CL552752" @default.
- NCIT_C150906 NCIT_P322 "CTRP" @default.
- NCIT_C150906 NCIT_P329 "793561" @default.
- NCIT_C150906 NCIT_P330 "793561" @default.
- NCIT_C150906 NCIT_P399 "793561" @default.
- NCIT_C150906 NCIT_R124 NCIT_C17828 @default.
- NCIT_C150906 NCIT_R124 NCIT_C17930 @default.
- NCIT_C150906 NCIT_R124 NCIT_C17937 @default.
- NCIT_C150906 NCIT_R124 NCIT_C18839 @default.
- NCIT_C150906 NCIT_R124 NCIT_C21124 @default.
- NCIT_C150906 NCIT_R124 NCIT_C45548 @default.
- NCIT_C150906 NCIT_R125 NCIT_C17828 @default.
- NCIT_C150906 NCIT_R125 NCIT_C17937 @default.
- NCIT_C150906 NCIT_R125 NCIT_C18095 @default.
- NCIT_C150906 NCIT_R125 NCIT_C18839 @default.
- NCIT_C150906 NCIT_R125 NCIT_C19053 @default.
- NCIT_C150906 NCIT_R125 NCIT_C21124 @default.
- NCIT_C150906 NCIT_R125 NCIT_C26280 @default.
- NCIT_C150906 NCIT_R125 NCIT_C40833 @default.
- NCIT_C150906 NCIT_R125 NCIT_C40912 @default.
- NCIT_C150906 NCIT_R72 NCIT_C104083 @default.
- NCIT_C150906 NCIT_R72 NCIT_C12219 @default.
- NCIT_C150906 NCIT_R72 NCIT_C12476 @default.
- NCIT_C150906 NCIT_R72 NCIT_C12508 @default.
- NCIT_C150906 NCIT_R72 NCIT_C12535 @default.
- NCIT_C150906 NCIT_R72 NCIT_C12542 @default.
- NCIT_C150906 NCIT_R72 NCIT_C12543 @default.
- NCIT_C150906 NCIT_R72 NCIT_C21599 @default.
- NCIT_C150906 NCIT_R72 NCIT_C32725 @default.
- NCIT_C150906 NCIT_R72 NCIT_C33061 @default.
- NCIT_C150906 NCIT_R72 NCIT_C38434 @default.
- NCIT_C150906 NCIT_R72 NCIT_C38439 @default.
- NCIT_C150906 NCIT_R72 NCIT_C39567 @default.
- NCIT_C150906 NCIT_R72 NCIT_C39568 @default.
- NCIT_C150906 normalizedInformationContent "100" @default.
- NCIT_C150906 referenceCount "1" @default.
- NCIT_C150906 hasExactSynonym "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-EGFRt T Cells" @default.
- NCIT_C150906 hasExactSynonym "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells" @default.
- NCIT_C150906 hasExactSynonym "CD19-CD8CD28zCAR-specific-mbIL15-HER1t T-lymphocytes" @default.
- NCIT_C150906 inSubset NCIT_C116977 @default.
- NCIT_C150906 inSubset NCIT_C116978 @default.
- NCIT_C150906 inSubset NCIT_C128784 @default.
- NCIT_C150906 inSubset NCIT_C176424 @default.
- NCIT_C150906 type Class @default.
- NCIT_C150906 isDefinedBy ncit.owl @default.
- NCIT_C150906 label "Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells" @default.
- NCIT_C150906 subClassOf NCIT_C129820 @default.
- NCIT_C150906 subClassOf NCIT_C129821 @default.
- NCIT_C150906 subClassOf NCIT_C129826 @default.
- NCIT_C150906 subClassOf NCIT_C137999 @default.
- NCIT_C150906 subClassOf NCIT_C142078 @default.
- NCIT_C150906 subClassOf NCIT_C150906 @default.
- NCIT_C150906 subClassOf NCIT_C154231 @default.
- NCIT_C150906 subClassOf NCIT_C176018 @default.
- NCIT_C150906 subClassOf NCIT_C1908 @default.
- NCIT_C150906 subClassOf NCIT_C1909 @default.
- NCIT_C150906 subClassOf NCIT_C1962 @default.
- NCIT_C150906 subClassOf NCIT_C200766 @default.
- NCIT_C150906 subClassOf NCIT_C274 @default.
- NCIT_C150906 subClassOf NCIT_C28681 @default.
- NCIT_C150906 subClassOf NCIT_C307 @default.
- NCIT_C150906 subClassOf NCIT_C308 @default.