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- NCIT_C151927 IAO_0000115 "A long-acting immunoglobulin (Ig) fusion protein composed of a recombinant form of the endogenous human protein interleukin-7 (rhIL-7) and fused to a hybrid Fc (hyFc) region of a human antibody, with hematopoietic and immunopotentiating activities. Upon administration of efineptakin alfa, IL-7 stimulates the proliferation, differentiation, trafficking and survival of a variety of T-cell subsets, including naive, central memory (CM), effector memory (EM), terminally differentiated effector memory (TEMRA) and natural killer (NK) T-cells, and enhances T-cell-mediated anti-tumor immune responses. Compared to rhIL-7 alone, fusion to the hyFc region enhances the half-life of IL-7. The hyFc region is composed of the hinge and N-terminal portion of heavy chain constant (CH) region 2 (hinge-CH2) of human IgD, which is fused to the C-terminal region of CH2 and the entire CH3 region of human IgG4." @default.
- NCIT_C151927 NCIT_NHC0 "C151927" @default.
- NCIT_C151927 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C151927 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C151927 NCIT_P107 "Efineptakin alfa" @default.
- NCIT_C151927 NCIT_P108 "Efineptakin alfa" @default.
- NCIT_C151927 NCIT_P208 "CL553266" @default.
- NCIT_C151927 NCIT_P210 "2026634-47-7" @default.
- NCIT_C151927 NCIT_P319 "3K3WC6MT6P" @default.
- NCIT_C151927 NCIT_P322 "CTRP" @default.
- NCIT_C151927 NCIT_P322 "FDA" @default.
- NCIT_C151927 NCIT_P329 "793669" @default.
- NCIT_C151927 NCIT_P330 "793669" @default.
- NCIT_C151927 NCIT_P366 "Glycosylated_Recombinant_Human_Interleukin-7" @default.
- NCIT_C151927 NCIT_P399 "793669" @default.
- NCIT_C151927 NCIT_R124 NCIT_C17828 @default.
- NCIT_C151927 NCIT_R124 NCIT_C18992 @default.
- NCIT_C151927 NCIT_R124 NCIT_C19143 @default.
- NCIT_C151927 NCIT_R124 NCIT_C21124 @default.
- NCIT_C151927 NCIT_R124 NCIT_C40702 @default.
- NCIT_C151927 NCIT_R125 NCIT_C17828 @default.
- NCIT_C151927 NCIT_R125 NCIT_C17937 @default.
- NCIT_C151927 NCIT_R125 NCIT_C18081 @default.
- NCIT_C151927 NCIT_R125 NCIT_C18095 @default.
- NCIT_C151927 NCIT_R125 NCIT_C18839 @default.
- NCIT_C151927 NCIT_R125 NCIT_C20480 @default.
- NCIT_C151927 NCIT_R125 NCIT_C20751 @default.
- NCIT_C151927 NCIT_R125 NCIT_C21124 @default.
- NCIT_C151927 NCIT_R125 NCIT_C26280 @default.
- NCIT_C151927 NCIT_R125 NCIT_C40833 @default.
- NCIT_C151927 NCIT_R125 NCIT_C40912 @default.
- NCIT_C151927 normalizedInformationContent "100" @default.
- NCIT_C151927 referenceCount "1" @default.
- NCIT_C151927 hasExactSynonym "EFINEPTAKIN ALFA" @default.
- NCIT_C151927 hasExactSynonym "Efineptakin alfa" @default.
- NCIT_C151927 hasExactSynonym "GX-I7" @default.
- NCIT_C151927 hasExactSynonym "Hyleukin-7 (TM)" @default.
- NCIT_C151927 hasExactSynonym "IL-7-hyFc" @default.
- NCIT_C151927 hasExactSynonym "Il-7 Hybrid Fc" @default.
- NCIT_C151927 hasExactSynonym "NT-I7 Recombinant Human Interleukin-7-hyFc" @default.
- NCIT_C151927 hasExactSynonym "NT-I7" @default.
- NCIT_C151927 hasExactSynonym "TJ 107" @default.
- NCIT_C151927 hasExactSynonym "TJ-107" @default.
- NCIT_C151927 hasExactSynonym "TJ107" @default.
- NCIT_C151927 hasExactSynonym "rhIL-7-hyFc" @default.
- NCIT_C151927 inSubset NCIT_C116977 @default.
- NCIT_C151927 inSubset NCIT_C116978 @default.
- NCIT_C151927 inSubset NCIT_C173381 @default.
- NCIT_C151927 inSubset NCIT_C173383 @default.
- NCIT_C151927 inSubset NCIT_C176424 @default.
- NCIT_C151927 inSubset NCIT_C63923 @default.
- NCIT_C151927 type Class @default.
- NCIT_C151927 isDefinedBy ncit.owl @default.
- NCIT_C151927 label "Efineptakin alfa" @default.
- NCIT_C151927 subClassOf NCIT_C1283 @default.
- NCIT_C151927 subClassOf NCIT_C151927 @default.
- NCIT_C151927 subClassOf NCIT_C1908 @default.
- NCIT_C151927 subClassOf NCIT_C1909 @default.
- NCIT_C151927 subClassOf NCIT_C307 @default.
- NCIT_C151927 subClassOf NCIT_C308 @default.
- NCIT_C151927 subClassOf NCIT_C592 @default.
- NCIT_C151927 subClassOf NCIT_C593 @default.