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- NCIT_C151932 IAO_0000115 "An orally bioavailable, binaphthol-sulfonamide-based inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. Upon oral administration, the STAT3 inhibitor C-188-9 specifically targets and binds to the phosphotyrosyl peptide binding site within the Src homology 2 (SH2) domain of STAT3. This inhibits the Janus kinase (JAK)-mediated tyrosine phosphorylation and activation of STAT3. This impedes nuclear translocation of STAT3, prevents STAT3 binding to responsive gene promoters and blocks STAT3-mediated regulation of gene expression. STAT3 regulates the transcription of genes involved in several cellular functions. STAT3 is constitutively activated in a variety of human cancers and plays a key role in neoplastic transformation, uncontrolled tumor cell proliferation, resistance to apoptosis, metastasis, immune evasion, tumor angiogenesis, epithelial-mesenchymal transition (EMT) and the Warburg effect." @default.
- NCIT_C151932 NCIT_A32 NCIT_C1909 @default.
- NCIT_C151932 NCIT_A7 NCIT_C28664 @default.
- NCIT_C151932 NCIT_NHC0 "C151932" @default.
- NCIT_C151932 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C151932 NCIT_P107 "STAT3 Inhibitor C-188-9" @default.
- NCIT_C151932 NCIT_P108 "STAT3 Inhibitor C-188-9" @default.
- NCIT_C151932 NCIT_P208 "CL553271" @default.
- NCIT_C151932 NCIT_P210 "432001-19-9" @default.
- NCIT_C151932 NCIT_P319 "KZ3DLD11RQ" @default.
- NCIT_C151932 NCIT_P322 "CTRP" @default.
- NCIT_C151932 NCIT_P322 "FDA" @default.
- NCIT_C151932 NCIT_P322 "GDC" @default.
- NCIT_C151932 NCIT_P329 "793126" @default.
- NCIT_C151932 NCIT_P330 "793126" @default.
- NCIT_C151932 NCIT_P375 "STAT3 Inhibitor TTI-101" @default.
- NCIT_C151932 NCIT_P399 "793126" @default.
- NCIT_C151932 normalizedInformationContent "100" @default.
- NCIT_C151932 referenceCount "1" @default.
- NCIT_C151932 hasExactSynonym "C188-9" @default.
- NCIT_C151932 hasExactSynonym "STAT3 Inhibitor C-188-9" @default.
- NCIT_C151932 hasExactSynonym "STAT3 Inhibitor TTI-101" @default.
- NCIT_C151932 hasExactSynonym "STAT3 Inhibitor XIII" @default.
- NCIT_C151932 hasExactSynonym "TTI 101" @default.
- NCIT_C151932 hasExactSynonym "TTI-101" @default.
- NCIT_C151932 hasExactSynonym "TTI101" @default.
- NCIT_C151932 inSubset NCIT_C116977 @default.
- NCIT_C151932 inSubset NCIT_C116978 @default.
- NCIT_C151932 inSubset NCIT_C128784 @default.
- NCIT_C151932 inSubset NCIT_C157711 @default.
- NCIT_C151932 inSubset NCIT_C157712 @default.
- NCIT_C151932 inSubset NCIT_C176424 @default.
- NCIT_C151932 inSubset NCIT_C177537 @default.
- NCIT_C151932 inSubset NCIT_C63923 @default.
- NCIT_C151932 type Class @default.
- NCIT_C151932 isDefinedBy ncit.owl @default.
- NCIT_C151932 label "STAT3 Inhibitor C-188-9" @default.
- NCIT_C151932 subClassOf NCIT_C151932 @default.
- NCIT_C151932 subClassOf NCIT_C1908 @default.
- NCIT_C151932 subClassOf NCIT_C1909 @default.
- NCIT_C151932 subClassOf NCIT_C200712 @default.
- NCIT_C151932 subClassOf NCIT_C2189 @default.
- NCIT_C151932 subClassOf NCIT_C274 @default.