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- NCIT_C151933 IAO_0000115 "The tosylate salt form of T-1101, an orally bioavailable inhibitor of highly expressed in cancer 1 (Hec1) and NIMA-related kinase 2 (Nek2), with potential antineoplastic activity. Upon oral administration, T-1101 specifically targets, binds to and inhibits the interaction of Hec1 with Nek2. This prevents Hec1/Nek2-mediated signal transduction pathways, inhibits mitosis, induces apoptosis and tumor cell proliferation. Hec1, overexpressed in some cancers, is located at the centromere during cell mitosis and plays an essential role in the pathway of spindle checkpoint. It is correlated with cancer formation, progression, and survival. Phosphorylation of Hec1 by Nek2 kinase is essential for its mitotic function." @default.
- NCIT_C151933 NCIT_A32 NCIT_C1909 @default.
- NCIT_C151933 NCIT_A7 NCIT_C138106 @default.
- NCIT_C151933 NCIT_A7 NCIT_C152016 @default.
- NCIT_C151933 NCIT_NHC0 "C151933" @default.
- NCIT_C151933 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C151933 NCIT_P108 "Hec1/Nek2 Inhibitor T-1101 Tosylate" @default.
- NCIT_C151933 NCIT_P208 "CL553272" @default.
- NCIT_C151933 NCIT_P322 "GDC" @default.
- NCIT_C151933 NCIT_P329 "793127" @default.
- NCIT_C151933 NCIT_P330 "793127" @default.
- NCIT_C151933 NCIT_P375 "Mitosis Inhibitor T 1101 Tosylate" @default.
- NCIT_C151933 NCIT_P399 "793127" @default.
- NCIT_C151933 normalizedInformationContent "100" @default.
- NCIT_C151933 referenceCount "1" @default.
- NCIT_C151933 hasExactSynonym "Hec1/Nek2 Inhibitor T-1101 Tosylate" @default.
- NCIT_C151933 hasExactSynonym "T 1101 Tosylate" @default.
- NCIT_C151933 hasExactSynonym "T1101 Tosylate" @default.
- NCIT_C151933 hasExactSynonym "TAI-95" @default.
- NCIT_C151933 inSubset NCIT_C128784 @default.
- NCIT_C151933 inSubset NCIT_C157711 @default.
- NCIT_C151933 inSubset NCIT_C157712 @default.
- NCIT_C151933 inSubset NCIT_C176424 @default.
- NCIT_C151933 inSubset NCIT_C177537 @default.
- NCIT_C151933 type Class @default.
- NCIT_C151933 isDefinedBy ncit.owl @default.
- NCIT_C151933 label "Hec1/Nek2 Inhibitor T-1101 Tosylate" @default.
- NCIT_C151933 subClassOf NCIT_C151933 @default.
- NCIT_C151933 subClassOf NCIT_C186664 @default.
- NCIT_C151933 subClassOf NCIT_C1908 @default.
- NCIT_C151933 subClassOf NCIT_C1909 @default.
- NCIT_C151933 subClassOf NCIT_C273 @default.
- NCIT_C151933 subClassOf NCIT_C274 @default.